Tadalafil All You Need to Know: Dosage, Benefits, and Side Effects

 »  »  Tadalafil All You Need to Know: Dosage, Benefits, and Side Effects


  1. What is Tadalafil?
  2. How Does Tadalafil Work?
  3. Who Uses Tadalafil?
  4. ED (Erectile Dysfunction) Growing Issue?
  5. Study & Development
  6. Benefits of Tadalafil
  7. Side Effects of Tadalafil
  8. Dosage
  9. FAQ (Frequently Asked Questions)
  10. Conclusion

Tadalafil is an FDA-approved erectile dysfunction medication. It is the longest-lasting erectile dysfunction medication on the market, with effects lasting up to 36 hours. 

What is Tadalafil?

Tadalafil is a prescription medication. It is available as an oral tablet. Tadalafil oral tablets are marketed under the brand names Cialis and Adcirca. There is also a generic version available. Generic drugs are typically less expensive than brand-name drugs. They may not be available in all strengths or forms as the brand-name drug in some cases.

Tadalafil is a medication that is used to treat male sexual function issues (impotence or erectile dysfunction-ED). Tadalafil works by increasing blood flow to the penis in conjunction with sexual stimulation to help a man obtain and maintain an erection. Tadalafil is also used to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH).

Tadalafil, like other erectile dysfunction medications, is a phosphodiesterase type 5 inhibitor, or PDE5 inhibitor. It works by increasing blood flow to your penis’ erectile tissue. When you’re sexually aroused, it’s easier to get and keep an erection. Tadalafil is a safe and effective medication for most men, and it is widely used by men of all ages and backgrounds in the United States and around the world. Aside from ED, what else is Tadalafil used for? Tadalafil is also commonly used to treat benign prostatic hyperplasia (BPH).

It aids in the relief of BPH symptoms such as difficulty starting the flow of urine, a weak stream, and the need to urinate frequently or urgently (including during the middle of the night). Tadalafil is thought to work by relaxing the smooth muscle in the prostate and bladder. However, this medication does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Use “safe sex” techniques such as latex condoms. For more information, speak with your doctor or pharmacist.

How Does Tadalafil Work?

Tadalafil (Cialis) is a medication used to treat benign prostatic hyperplasia (BPH), erectile dysfunction (ED), or both. Tadalafil (Adcirca) is a medication that is used to treat pulmonary arterial hypertension (PAH).

The prostate gland enlarges but is not cancerous in BPH. It has the potential to pinch or squeeze your urethra (the tube that carries urine from the kidneys out of the body). BPH symptoms include difficulty urinating, painful urination, and an urgent or frequent need to urinate.

When a man is sexually excited, the penis does not fill with enough blood to harden and expand. ED can also make it difficult for a man to maintain an erection. PAH is a rare but serious type of hypertension. It manifests itself in the pulmonary arteries, which are blood vessels in the lungs.

Who Uses Tadalafil

For pregnant women, there has been no evidence of fetal risk in studies of this drug in pregnant animals. However, there haven’t been enough studies conducted in pregnant women taking the drug for PAH to determine whether the drug is harmful to a human fetus.

If you are pregnant or intend to become pregnant, consult your doctor. Animal studies do not always predict how humans will react. As a result, this medication should only be used during pregnancy if absolutely necessary.

It is unknown whether tadalafil passes into breast milk in women who are breastfeeding. If it does, it could have serious consequences for a breastfed child. If you’re taking tadalafil and want to breastfeed, consult your doctor.

Seniors 65 or older, your body may process this medication more slowly. Your doctor may start you on a lower dose to avoid excessive tadalafil buildup in your body. High levels of the drug in your system can be harmful. Tadalafil should not be used by children under the age of 18. It is unknown whether tadalafil is both safe and effective in children.

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ED (Erectile Dysfunction) Growing Issue?

Erectile Dysfunction is turning into a growing concern across the globe, as men of all ages will most likely experience this due to the condition of the world. Factors that contribute to this issue are obesity, old age, diabetes, depression, heavy alcohol consumption, and smoking. 

A lot of men take this issue seriously as the inability to achieve and sustain an erection derails them of sexual gratification for themselves and their partner. Today, a lot of people have science to be thankful for, as day-by-day innovative research and an array of medicinal solutions serve as a beacon of hope and solution to men around the world. 

Fortunately, there are a number of ways to treat ED, with each specifically tailored to a person’s needs and desires. 

  • Oral Medication 
  • Sex Therapy 
  • Injections 
  • Vacuum devices 
  • Surgery 
  • Intraurethral medication

Being able to pinpoint the main reason raises the chances of finding the underlying cause and eventually the necessary solution. One said viable solution is Tadalafil, a medicinal peptide specifically engineered and formulated to treat erection problems and enlarged prostate. It also has pulmonary hypertension treatment for those who are in need. Taking it on its own is more than enough to get you hard and all without any risk involved.

Study and Development

Increased penile blood flow caused by relaxation of penile arteries and corpus cavernosal smooth muscle causes penile erection during sexual stimulation. The release of nitric oxide (NO) from nerve terminals and endothelial cells stimulates the synthesis of cGMP in smooth muscle cells, resulting in this response. Smooth muscle relaxation and increased blood flow into the corpus cavernosum are caused by cyclic GMP. By increasing the amount of cGMP, phosphodiesterase type 5 (PDE5) inhibition improves erectile function. PDE5 is inhibited by tadalafil. Because sexual stimulation is required to initiate the local release of nitric oxide, tadalafil’s inhibition of PDE5 has no effect in the absence of sexual stimulation.

PDE5 inhibition reduces cGMP concentrations in the corpus cavernosum and pulmonary arteries, as well as in the smooth muscle of the prostate, bladder, and their vascular supply. The mechanism for alleviating BPH symptoms is unknown.

In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 is found in the corpus cavernosum, prostate, and bladder smooth muscles, as well as vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas.

In vitro studies have shown that tadalafil has a stronger effect on PDE5 than on other phosphodiesterases. According to these studies, tadalafil is more than 10,000-fold more potent for PDE5 than for PDE1, PDE2, PDE4, and PDE7 enzymes found in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle, and other organs. Tadalafil is >10,000-fold more effective against PDE5 than it is against PDE3, an enzyme found in the heart and blood vessels. Furthermore, tadalafil is 700-fold more effective against PDE5 than PDE6, which is found in the retina and is responsible for phototransduction. Tadalafil is >9,000-fold more effective against PDE5 than it is against PDE8, PDE9, and PDE10.

Tadalafil inhibits PDE5 14-fold more than PDE11A1 and 40-fold more than PDE11A4, two of the four known forms of PDE11. PDE11 is an enzyme that can be found in the human prostate, testes, skeletal muscle, and other tissues (e.g., adrenal cortex). Tadalafil inhibits human recombinant PDE11A1 and, to a lesser extent, PDE11A4 activities in vitro at therapeutic concentrations. In humans, the physiological role and clinical consequences of PDE11 inhibition are unknown.

Benefits of Tadalafil

Tadalafil (Tadalafil) is used to treat erectile dysfunction (ED, impotence; inability to get or maintain an erection) and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate) in adult men, including difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. Tadalafil (Adcirca) is a medication used to improve exercise capacity in people with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness).

Tadalafil belongs to a class of drugs known as phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation to treat erectile dysfunction. An erection can result from increased blood flow. Tadalafil works to treat PAH by relaxing blood vessels in the lungs, allowing blood to flow more freely.

If you’re taking tadalafil to treat erectile dysfunction, you should know that it doesn’t cure it or increase sexual desire. Tadalafil does not prevent pregnancy or the spread of sexually transmitted diseases such as HIV (HIV).

Side Effects of Tadalafil

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment. The most common side effects of Tadalafil include:

  • Headache,
  • Flushing (Warmth, Redness, Or Tingly Feeling),
  • Nausea,
  • Upset Stomach,
  • Runny Or Stuffy Nose,
  • Muscle Pain,
  • Back Pain, And
  • Pain In Your Arms Or Legs
  • Chest Pain,
  • Pain Spreading To The Jaw Or Shoulder,
  • Nausea,
  • Sweating,
  • Vision Changes,
  • Sudden Vision Loss,
  • Ringing In Your Ears,
  • Sudden Hearing Loss, And
  • An Erection That Is Painful Or Lasts Longer Than 4 Hours


Before you begin taking tadalafil, and each time you get a refill, read the Patient Information Leaflet provided by your pharmacist. If you have any concerns, consult your doctor or pharmacist. As directed by your doctor, take this medication by mouth, with or without food. Tadalafil should not be taken more than once per day. This medication should be swallowed whole, according to the manufacturer. Many similar drugs (immediate-release tablets) can, however, be split/crushed. Follow your doctor’s instructions for taking this medication.

The dosage is determined by your medical condition, response to treatment, and any other medications you are taking. Inform your doctor and pharmacist about all of the products you use (including prescription drugs, nonprescription drugs, and herbal products). Take this medication as directed by your doctor, usually once a day, to treat the symptoms of BPH. If you are also taking finasteride to treat BPH symptoms, consult your doctor about how long you should continue taking this medication.

Tadalafil can be prescribed in two ways to treat erectile dysfunction-ED. Your doctor will advise you on the best way to take tadalafil. Follow your doctor’s instructions exactly because your dosage is determined by how you take it. The first method is to take it as needed, usually 30 minutes before sexual activity. The effect of tadalafil on sexual ability can last up to 36 hours. The second method of treating ED is to take tadalafil on a daily basis, once a day. If you take it this way, you can engage in sexual activity at any time in between doses.

If you’re taking tadalafil to treat both ED and BPH, follow your doctor’s instructions and take it once a day. You may engage in sexual activity at any time between doses. If you take tadalafil once daily for BPH, ED, or both, make sure you take it on a regular basis to get the most out of it. Take it at the same time every day to help you remember. If your condition does not improve or worsens, notify your doctor.


How long does Tadalafil stay in your system?

Tadalafil can stay in the body for up to 36 hours, so it’s best to avoid taking more than one tablet in a 24-hour period. It’s also worth noting that in order to feel the effects of the ED tablet, you must be sexually aroused.

Is Tadalafil effective at lowering blood pressure?

Tadalafil works by widening blood vessels in the body, allowing blood to flow more freely. As a result, the medication may help lower blood pressure.

Is tadalafil more potent than Viagra?

Tadalafil and Viagra both treat erectile dysfunction, with the main difference being how long tadalafil lasts in comparison to tadalafil. Tadalafil can stay in the body for up to 36 hours, whereas Viagra can stay in the body for up to 5 hours.

How long should you take tadalafil before having sex? 

Tadalafil can be prescribed in two ways: as a daily dose or as an as-needed dose. Either one will be prescribed by your doctor. If you take tadalafil as needed, you should take it at least 30 minutes before sex. If you take it on a daily basis, try to take it at the same time every day.

How frequently should tadalafil be taken? 

Tadalafil should be taken no more than once every 24 hours. If you miss a dose during this time, take it as soon as possible. Never, however, double your doses. If you miss a dose and your next dose is already scheduled, skip the missed dose.


In conclusion, there is a pro-inflammatory environment in the blood of BPH/LUTS-ED patients, which may have an effect on cognitive functions and auditory evoked potential. Tadalafil inhibits PDE5 and has an anti-inflammatory effect, as well as improving psychometric tests and MMN parameters. Tadalafil may be a promising candidate for chronic treatment in other inflammatory pathologies associated with mild cognitive impairment because it requires less frequent administration than other PDE5 inhibitors and is safe in chronic treatments.

Tadalafil, like other PDE5 inhibitors, effectively improves the ability of men with erectile dysfunction to achieve an erection and complete intercourse. It is less effective, but still useful, in some diabetic men with ED. Because of its longer duration, it may necessitate fewer dosings and allow the user to take it earlier in the day of planned sexual activity. However, some experts believe that because sildenafil has a longer track record of safety, it should be preferred over tadalafil.

Tadalafil is safe and well tolerated in doses of 5, 10, or 20mg taken as needed up to once daily for 18 to 24 months. These findings lend support to the long-term use of tadalafil in the treatment of erectile dysfunction.

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The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.