Arimidex Full Guide: Benefits, Dosage, and Effects

 »  »  Arimidex Full Guide: Benefits, Dosage, and Effects


  1. What is Arimidex?
  2. How Does It Work?
  3. Who Uses Arimidex?
  4. Arimidex as a PCT
  5. Study & Development
  6. Benefits
  7. Side Effects
  8. Dosage
  9. FAQ (Frequently Asked Questions)
  10. Conclusion

Bodybuilders who use anabolic steroids to boost muscle mass and sports performance may encounter a variety of side effects. Increased estrogen levels can cause males to develop breasts in some situations.

Arimidex inhibits breast growth in men by lowering estrogen levels. However, the medicine has its own set of negative effects.

We’ll go over what Arimidex accomplishes, why bodybuilders could use it, and the potential adverse effects.

What is Arimidex?

Arimidex is an anti-estrogen aromatase inhibitor (AI) medicine that was developed to treat postmenopausal women with breast cancer and is still used for that purpose today. It is also used in bodybuilding to reduce the effect of other steroids. Arimidex’s generic name is Anastrozole, and while there are a few different brand names for it around the world, Arimidex is by far the most popular and well-known.

The Arimidex brand is well-known among steroid users as a treatment for the estrogenic adverse effects that many anabolic steroids cause. Arimidex is almost usually advised for usage in a steroid cycle for this purpose. Arimidex (anastrozole) reduces estrogen levels in postmenopausal women, which may inhibit the growth of breast cancers that require estrogen to thrive. Arimidex is a drug that is used to treat postmenopausal women with breast cancer.

How Does It Work?

Arimidex works by inhibiting the aromatase enzyme, which reduces the amount of estrogen in the body. This is important for treating breast cancer because of estrogen’s influence on cancer cells, but it also serves a useful purpose for steroid users because estrogen is the steroid’s worst enemy and causes many of the terrible side effects we all want to avoid.

Arimidex is one of the most efficient aromatase inhibitors for addressing the estrogenic adverse effects of aromatizing steroid use, such as gynecomastia, water retention, and elevated blood pressure that often accompany excess water retention.

Fortunately,  Dr. O’connor discusses two of the main aromatize inhibitors, Arimidex and Aromasin. What are the differences, what role do they play, and is there an advantage of one over the other?

Who Uses Arimidex?

Arimidex is used as a Post Cycle Therapy by bodybuilders since it decreases estrogen production. Both male and female bodies rely on this hormone for a variety of tasks. Its high levels in men’s systems, however, cause gynecomastia, or breast enlargement. Arimidex aids in the prevention of this.

While bodybuilders are on performance-enhancing drugs, they take Aromatize Inhibitors to prevent Testosterone (and other drugs) from converting into Estrogen. In this video specifically, we’ll be talking about Anastrozole (Arimidex).

Arimidex accomplishes this by inhibiting the production of estrogen in the body. As a result, the flow of female hormones to the breast tissue is reduced. The ability of the breast tissue to expand plummets as the incoming supply of fuel (estrogen) that it requires to grow is exhausted.

Arimidex as a PCT

Arimidex has the ability to enhance natural testosterone production in males, which can be beneficial during post-cycle therapy when the goal is to re-establish natural testosterone levels after a cycle has severely lowered them. Keep in mind that Arimidex alone will not be strong enough as a testosterone stimulant for most guys, and others will choose not to use it at all in post-cycle therapy. The major reason Arimidex isn’t used in post-cycle therapy is because of its potent estrogen-lowering impact, which might cause hormone levels to drop too low to sustain appropriate bodily functioning in some circumstances.

While estrogen is not a primary hormone for guys, it is still essential, and the use of Arimidex during post-cycle therapy can block this important function, resulting in a lack of the therapeutic effects you require. This may come as a surprise to new steroid users who believe that AIs, with their outstanding estrogen-reduction capabilities, must be the best option for post-cycle therapy as well, but the majority of users will choose for SERMs like Nolvadex and Clomid.

Study and Development

Arimidex is a hormone medication for the treatment of some types of breast cancer. It’s an aromatase inhibitor, a sort of medication. Arimidex works by reducing the activity of an enzyme known as aromatase. (Enzymes are proteins that aid in the chemical reactions that occur within your body.) The aromatase enzyme converts testosterone and other steroid hormones into estrogen. Aromatase is found in the brain, fat, and skin, among other tissues.

Your ovaries produce the majority of estrogen before menopause. The aromatase enzyme produces only a modest quantity. Your ovaries, however, quit generating estrogen after menopause. At that moment, the aromatase enzyme is the primary source of estrogen in your body. (And the aromatase enzyme is also responsible for the majority of estrogen production in men.) Arimidex reduces the amount of estrogen in your body by inhibiting aromatase. This inhibits estrogen’s ability to promote the growth and spread of breast cancer.

Arimidex is not known to interact with alcohol. However, if you are taking Arimidex and have specific adverse effects, drinking alcohol may make them worse. Headaches, dizziness, nausea, and weariness are some of the negative effects. Drinking a lot of alcohol while taking Arimidex can make you more prone to osteoporosis (weak, thin bones). Because of this danger, it’s advisable to avoid consuming a lot of alcohol when taking Arimidex.

Alcohol consumption has also been linked to an increased risk of breast cancer. However, it’s unclear if drinking alcohol after being diagnosed with breast cancer will make it worse or make it more likely to return following treatment. Consult your doctor if you drink alcohol and are concerned about how it might influence your breast cancer or treatment. They can advise you on how much alcohol is safe to consume.

Estrogens promote or maintain the growth of a variety of breast cancers. Estrogens are produced principally by the aromatase enzyme, which transforms adrenal androgens (mostly androstenedione and testosterone) to estrone and estradiol in postmenopausal women. By blocking the aromatase enzyme selectively, estrogen biosynthesis can be suppressed in peripheral tissues as well as in cancer tissue itself. Anastrozole is a non-steroidal aromatase inhibitor that is selective. It reduces serum estradiol levels considerably while having no effect on the production of adrenal corticosteroids or aldosterone.

Multiple daily dosing trials with 0.5, 1, 3, 5, and 10 mg of ARIMIDEX in postmenopausal women with advanced breast cancer investigated mean serum concentrations of estradiol. All doses resulted in a clinically substantial decrease in serum estradiol. The mean estradiol serum concentrations were suppressed to the lower limit of detection (3.7 pmol/L) at doses of 1 mg and higher. Arimidex 1 mg, the recommended daily dose, lowered estradiol by nearly 70% in 24 hours and by approximately 80% after 14 days of regular dosing. After stopping Arimidex 1 mg daily treatment, serum estradiol suppression was sustained for up to 6 days.

The selectivity of anastrozole was determined by analyzing effects on corticosteroid synthesis in several daily dosage trials with 3, 5, and 10 mg. Anastrozole had no effect on cortisol or aldosterone secretion at baseline or in response to ACTH at any dose. Anastrozole does not require glucocorticoid or mineralocorticoid replacement medication.

Thyroid-stimulating hormone (TSH) was assessed in repeated daily dosing trials with 5 and 10 mg; there was no rise in TSH following ARIMIDEX treatment. In animals, Arimidex has no direct progestogenic, androgenic, or estrogenic activity, but it does affect the levels of progesterone, androgens, and estrogens in the blood.


Prevents Gynecomastia

Gynecomastia is one of the most frequent male breast problems, according to statistics. In early to mid-puberty, up to 70% of boys and men develop ‘man boobs.’ Due to regular hormone changes, the majority of them develop gynecomastia. However, some people get it as a result of using anabolic steroids. Arimidex, regardless of the cause, aids in the prevention of this condition. It does that by slowing down the production of the fuel (estrogen) that breast tissues need to grow. In doing so, this drug helps treat a ‘problem’ that has been nagging bodybuilders for ages.

Could Help With Fertility

High estrogen levels have been linked to male infertility in peer-reviewed studies. Estrogen levels that are too high can cause sperm counts to decline. Infertility may ensue from the ensuing drop in sperm count. As a result, estrogen management is required. The good news is that Arimidex, which was originally created to treat breast cancer, has shown promise in restoring male fertility. It accomplishes this by blocking aromatase and delaying testosterone conversion to estrogen. This aids Arimidex in improving male sperm production.

Erectile Dysfunction (ED) Treatment

Bodybuilders with erectile dysfunction don’t have this problem because they lift weights. Instead, their use of anabolic steroids and other dangerous medicines may have harmed their capacity to obtain and maintain a firm adequate erection for intercourse. Arimidex Anastrozole was found to help males with sexual dysfunction in one research. The study, which focused on male subjects with hypogonadism and epilepsy, discovered that 3-month treatment with Arimidex improved sexual performance in 72 percent of the participants. Within a month, combining Arimidex PCT treatment with penile pumps like the Bathmate could significantly help your erectile dysfunction (or even shorter, depending on the severity of your condition).

Side Effects

Arimidex disrupts hormone production in the body, which can result in a variety of negative effects. Lower estrogen levels, for example, can cause bone loss and weakness. Other typical adverse effects include the following:

  • joint discomfort
  • vomiting and nausea
  • bursts of heat
  • weakness
  • tiredness
  • swell all throughout the body
  • chest discomfort
  • eyesight problems
  • heartbeats per minute
  • rashes
  • breast discomfort


After learning what Arimidex is, why bodybuilders use it, and the potential benefits it has for the general male population, it’s time to tackle the most important question: how much Arimidex should you take on a daily basis?

Arimidex should be used in doses of 0.5 to 1 mg each day, according to users. Given that this medicine is generally accessible in 1 mg tablets, this is fairly simple. You can take Arimidex every other day if you think the prescribed dosage is too much for you.

Because Arimidex is used to prevent gynecomastia, you should continue your Arimidex cycle alongside your anabolic steroid cycle. That isn’t to say that both cycles should be started at the same time. In fact, users suggest starting your Arimidex cycle when you’re already two weeks into the steroid cycle.

This will provide you with two advantages. You’ll be able to prevent the side effects of Arimidex if you’re already on a steroid/supplement cycle when you start taking it. At the same time, it will enable Arimidex to achieve its goals.


What happens if I forget to take a dose?

Take the drug as soon as possible, but if your next dose is approaching, avoid the missed dose. Do not combine two dosages at once.

What happens if I take too much?

Seek emergency medical help from your doctor or the emergency hospital as soon as possible.

What should I stay away from?

Avoid driving or engaging in dangerous activities until you have a better understanding of how this medicine may affect you. It’s possible that your reactions will be hampered.

How much does Arimidex reduce estrogen levels?

The FDA claims that taking one Arimidex tablet for one day reduces estrogen by 70% in the first 24 hours. This medicine can lower estrogen by 80% after a fortnight of daily use. After you’ve finished the Arimidex cycle, the suppressed levels won’t return for up to 6 days.

How quickly does Arimidex reduce estrogen levels?

Arimidex begins decreasing estrogen within 24 hours following the first dose, according to health experts. Still, it could take up to seven days for the medicine to reach peak levels in the blood plasma.

What happens if you don’t take Arimidex anymore?

The drug that remains in your body after you stop taking Arimidex will be gradually broken down by your liver. The length of time Arimidex remains in your system varies from person to person. However, the majority of the medicine is normally eliminated from your body within 10 days.


Arimidex is an anti-estrogen that is used to treat estrogenic adverse effects of steroid use such as gynecomastia, water retention, and low testosterone levels. Arimidex reduces estrogen levels by inhibiting the enzyme aromatase, which converts testosterone to estrogen.

Arimidex was first designed to treat postmenopausal women with breast cancer. However, its aromatase-inhibiting abilities have piqued the interest of bodybuilders looking for a safe way to naturally lower their estrogen levels.

Several pieces of evidence indicate that it accomplishes exactly that. Keep in mind that no human studies have been conducted to confirm the effects of Arimidex on male breast tissue. As a result, it is recommended that you seek medical advice before beginning Arimidex post-cycle therapy.

Before taking any drug that alters regular hormone production, it’s advisable to talk to your doctor. Other drugs or medical disorders that impact hormone levels may be present in certain patients. In certain circumstances, taking Arimidex could lead to more significant problems. If you see signs of an adverse response, such as swelling or rashes, you should stop taking the medication and visit a doctor right away.

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The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.