Epitalon Full Guide: Benefits, Dosage, and Effects

 »  »  Epitalon Full Guide: Benefits, Dosage, and Effects

  1. What is Epitalon?
  2. How Does Epitalon Work?
  3. Who Uses Epitalon?
  4. Study & Development
  5. Epitalon for Women
  6. Benefits of Epitalon
  7. Side Effects of Epitalon
  8. Dosage
  9. FAQ (Frequently Asked Questions)
  10. Conclusion

Epithalon (sometimes written Epithalon or Epithalone) is a synthetic version of Epithalamin, a peptide produced by the pineal gland in the brain. The pineal gland is a small pea-shaped gland that is frequently referred to as the “third eye.” It is well known for secreting melatonin, a hormone that regulates our sleep/wake cycles. 

Epitalon is a four-amino-acid peptide that has been dubbed “the fountain of youth.” Alanine, glutamic acid, glycine, and aspartic acid are the four amino acids. Peptides are two to fifty-chain amino acids that differ from proteins in that they have fewer chains (proteins have more than fifty chains). 

This peptide boosts natural telomerase production, an enzyme that helps cells make telomeres, the functional sections of our DNA. Telomere production aids the body in the synthesis of new cells and the rejuvenation of old ones.

What is Epitalon?

The synthetic form of the polypeptide Epithalamin, which is naturally produced in the pineal gland, is Epithalon (also known as Epitalon or Epithalone). Professor Vladimir Khavinson, a Russian scientist, discovered it and spent the following 35 years conducting epitalon-related research in both animal and human clinical trials.

Epitalon’s main function is to boost natural telomerase synthesis, which helps cells replicate telomeres, which are the protecting sections of our DNA. This permits our DNA to replicate, allowing our bodies to produce new cells and regenerate existing ones.

Younger people have more telomerase and longer telomeres than older folks. The more telomere strands there are, the greater the cell’s health and replication. However, as humans age, their telomerase production decreases, and their cell replication and health suffer as a result. This is the primary cause of aging.

Epitalon also helps to regulate metabolism by boosting hypothalamic sensitivity to natural hormonal stimuli, balancing anterior pituitary function, and regulating gonadotropin and melatonin levels in the body.

In a cell culture of human fetal fibroblast cells, telomere elongation by epitalon was sufficient to surpass the Hayflick limit, extending their proliferative potential from termination at the 34th passage in the control cell population to beyond the 44th passage in the treated cell population, while increasing telomere lengths to levels comparable to those of cells in the original culture.

In cultured lymphocytes derived from samples taken from humans aged 76 to 80 years, epitalon causes decondensation of heterochromatin near the centromeres. In aged skin fibroblasts, Epitalon appears to decrease MMP9 protein synthesis in vitro

How Does Epitalon Work?

The pineal gland in the brain is where Epitalon works. Its main function is to boost the synthesis of telomerase, a natural enzyme that aids in the replication of telomeres, the protecting sections of our DNA. This lets our DNA replicate, allowing the body to produce new cells and regenerate existing ones. In somatic cells, it showed a 33 percent increase in telomere length.

It has a number of well-documented effects on aging and the circadian rhythm. It encourages a natural cycle and healthy sleep patterns, as well as ensuring that cortisol and other stress chemicals are not raised throughout the day, which can lead to belly fat accumulation. It aids in the regulation of melatonin and cortisol levels.

Who Uses Epitalon?

​​Epitalon is widely used in sports as a bodybuilding peptide, in cosmetics, and in medicine to speed up the recovery of physical activity and restore energy balance lost after workouts. Epitalon is known as AGAG in the sports world because of its structure, which is a chain of four amino acids. This short peptide has been known for over 30 years. The chemical was discovered in animal brain extracts. It was first tested on animals.

Epitalon has a regenerative and life-prolonging impact, as well as a favorable effect on hormone levels and the thyroid gland, according to study. Epitalon aids in the prevention of early cell aging. Epitalon-based analogs of this peptide were later created (Epitalamin, Endoluten, and Pineamin). Epitalon, on the other hand, takes the lead among them.

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Study and Development

Epitalon is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly, a molecular weight of 390.35 g/mol, and a molecular formula of C14H22N4O9. Epitalon is generated from Epithalamin (Epithalamine), a polypeptide produced in the pineal gland that occurs naturally in the body. Epitalon’s capacity to boost telomerase activity in somatic cells is a very useful and unique feature. This aids the replication of telomeres, which are key “protective sections” of our DNA, resulting in a slowing of the aging process.

In addition, scientific research has indicated that Epitalon may have additional significant potential benefits, such as cancer and age-related diseases prevention, melatonin restoration and normalization, stimulation of deeper sleep, and powerful antioxidant characteristics. Professor Khavinson patented Epitalon, which was approved for general use in Russia in 1990 and has since been utilized in gerontology. Epitalon has been the subject of several scientific studies and clinical trials in both animals and humans, with no serious side effects observed to yet.

Epitalon therapy dramatically reduced the incidence of chromosomal abnormalities in aging mice, both in wild-type mice and mice with an accelerated aging phenotype, which is associated with improvements in telomere length, according to an in vivo research in aging mice. Epitalon boosted the activity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase in another investigation in aging rats. Epithalamin boosted overall antioxidant capacity by 36% and superoxide dismutase (SOD, a potent endogenous antioxidant) activity by 19% in male rats.

Many diseases, including heart disease, cancer, diabetes, and even neurological disorders like Alzheimer’s and Parkinson’s, are caused by oxidative stress, which happens when the body lacks antioxidants to counteract the effects of free radicals (damaging molecules that are missing electrons). Melatonin is one of the most powerful endogenous antioxidants produced by the body. The antioxidant properties of Epitalon are assumed to be attributable in part to its capacity to boost Melatonin production as well as mechanisms other than Melatonin activity.

In an investigation on one-year-old female C3H/He mice, epitalon reduced the number of spontaneous tumors and metastases in mice that did develop spontaneous tumors, and is thought to have oncostatic and anti-metastatic characteristics.

A human prospective cohort study of 266 people over the age of 60 found that treatment with epithalamin, the pineal gland extract on which epitalon is based, resulted in a 1.6–1.8-fold reduction in mortality over the next 6 years, a 2.5-fold reduction in mortality when combined with thymulin, and a 4.1-fold reduction in mortality when combined with thymulin and administered annually rather than once at study onset.

Epitalon for Women

Both epitalon and epithalamin dramatically raised telomere lengths in the blood cells of patients aged 60-65 and 75-80 in human clinical trials, and its efficacy was equal. In both old monkeys and humans, epitalon and epithalamin appear to restore melatonin release by the pineal gland. In a human clinical experiment involving a group of retinitis pigmentosa patients, epitalon was found to have a good clinical effect in 90% of instances in the treated group.

Epitalon does not have a direct link with how it affects women but it did not appear to correct pre-existing structural aberrations of chromosomes associated with telomere degradation in another human clinical trial conducted on a sample of pulmonary tuberculosis patients, but it did appear to protect against the development of additional chromosomal aberrations in the future.

Benefits of Epitalon

The benefits of Epitalon’s effect on telomerase production are one-of-a-kind and far-reaching, including:

  • Increases the lifetime of human cells by lengthening their telomeres.
  • It encourages you to sleep longer.
  • Cancer, heart disease, and dementia are all age-related disorders that can be delayed or prevented.
  • Reduces lipid oxidation and reactive oxygen species (ROS) while also restoring T cell activity as an antioxidant.
  • Improves the health and look of the skin
  • Heals muscle cells that have been harmed or are degrading.
  • Melatonin levels are restored and normalized in persons who have lost some pineal function owing to age.
  • Can help you become more resistant to emotional stress.
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Side Effects of Epitalon

​​Epitalon, like other peptides such as BPC 157 and Ipamorelin, imitates an enzyme that exists naturally in the body. Epitalon is generally safe and does not have any negative side effects. It also doesn’t contain any hormones, which means it’s much less likely to cause negative side effects. You may have the following side effects if you use Epitalon injections:

  • The injection site is swollen and red
  • Nausea


The peptide can be supplied in a variety of ways, according to the instructions. It’s worth noting that the oral technique is the most time-consuming and ineffectual. In the world of athletics, the intramuscular route of administration of the medication is preferred. Under-the-skin injections of the active ingredient ensure that the medicine enters the bloodstream quickly.

The number of cycles is determined by the athlete’s desired outcome as well as the body’s particular characteristics. It is recommended that you see a sports coach before injecting the peptide. This will aid in the prevention of undesired side effects and other issues. The effectiveness of Epitalon is directly proportional to your weight, age, peptide dosage, and injection time. For athletes, the following peptide cycle is recommended:

  • The suggested daily dosage is 5-15mcg per 1 kg of body weight.
  • The cycle lasts two months, or around two vials;
  • After a two-month cycle, it’s best to take a break.
  • It is recommended that you thoroughly examine the peptide’s composition as well as the guidelines for its usage and dilution before using it for the first time. This will allow you to precisely dial in the dosage and avoid an allergic reaction.

The peptide is taken orally at a dose of 400-600mcg per day (the dosage should be divided into 2-3 doses). Epitalon is sprayed at a rate of 1 to 30 milligrams each day (the dosage is divided into 3 uses).


What is the purpose of Epitalon?

Epitalon is used to boost telomerase synthesis, a natural enzyme that aids in the replication of telomeres, which are the protective sections of our DNA. The aging of cell populations is slowed as a result of this, and the aging of cell populations correlates with the total physical aging of an organism. Epitalone, on the other hand, can be utilized to restore and normalize melatonin levels as well as protect cells from oxidative stress.

Is Epitalon capable of slowing down the aging process?

Epitalon has been shown in scientific studies and clinical trials to halt the aging process and has powerful anti-aging qualities.

Is Epitalon capable of preventing cancer?

Epitalon does, in fact, have the power to prevent cancer.

​​Can Epitalon help you sleep better?

Yes, Epitalon promotes and regulates Melatonin production, resulting in a better and deeper sleep.

What is the best way to administer Epitalon?

Intravenous, intramuscular, or transdermal / subcutaneous (under the skin, through the skin) injections are the most common ways to deliver Epitalon. Because the peptides are broken down/cleaved in the gastrointestinal tract, oral delivery is ineffective. This means they are unable to travel through the gastrointestinal tract in a functional and undamaged state, allowing them to exercise their effects in the bloodstream.

Are there any side effects to Epitalon?

Epitalon has not been proven to have any significant side effects, unwanted effects, or hazardous consequences in clinical trials.


Epitalon is a synthetic tetrapeptide that stimulates the formation of telomerase. Telomerase aids in the renewal of telomeres, which are the “protective sections” of our DNA, resulting in a slowing of the aging process. Epitalon has undergone comprehensive testing in both animal and human trials. Epitalon slows the aging of cell populations, has powerful anti-aging and antioxidant characteristics, helps defend against cancer and age-related disorders, normalizes Melatonin production by the Pineal gland, and promotes quality sleep, according to scientific studies and clinical testing.

Epitalon has a lot of advantages that can aid with aging symptoms. It also functions as an antioxidant and improves mood. Telomerase synthesis and telomere rejuvenation have been demonstrated to be important in combating aging symptoms in numerous studies. Epitalon has been proven to enhance telomerase production, which strengthens and lengthens telomeres, implying that Epitalon can help slow down the aging process and so prolong human longevity

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The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.