PT-141(Bremelanotide) Ultimate Guide: Dosage, Side effects, and Benefits

 »  »  PT-141(Bremelanotide) Ultimate Guide: Dosage, Side effects, and Benefits


  1. What is PT-141?
  2. How Does PT-141 Work?
  3. Study & Development
  4. Benefits
  5. Side Effects
  6. PT-141 for Men & Women
  7. Dosage
  8. FAQ (Frequently Asked Questions)
  9. Conclusion

PT 141 is an exciting peptide hormone that improves both male and female sexual function. This synthetic peptide is used to treat erectile dysfunction and low libido in men. After using it, several women who had not experienced sexual arousal in years became sexually active.

Read more below to find out how this product can help you!

What is PT-141?

PT 141 is a peptide derived from melanocortin. It was created to assist premenopausal women who had lost their sexual desire for no obvious cause. Over time, though, it has shown promise for everyone, including 50% of impotent males who aren’t helped by Viagra.

PT 141 and Viagra are both aphrodisiacs, but they don’t work in the same way. Viagra works by boosting the flow of blood to the penis. On the other hand, PT 141 gets right to the brain. The neurological circuit responsible for making you feel sexually stimulated is then activated.

This strategy allows it to slay two birds with one stone. PT 141 can assist you in achieving and maintaining an erection for long periods of time (something Viagra can also do). It might also assist you in putting yourself in a good mood (something Viagra cannot). It’s no surprise that some people claim it’s a cure-all for all their sexual problems.

In a nutshell, PT 141 is a fantastic technique to increase sexual desire, arousal, and general sexual activity. It may also aid in the treatment of sexual dysfunction and erectile dysfunction.

How Does PT-141 Work?

PT 141 is a previously agreed-upon development code for Bremelanotide. It is a peptide that was initially developed as a murky tanning product. The peptide hormone is now used to help both men and women improve their sexual function. The treatment has been shown to be efficient and effective in increasing libido in men and reversing sexual arousal issues in women. The use of PT 141 supplement, a safe ED treatment that has been shown to provide the desired sexual arousal in people within minutes, is one standard treatment.

Intranasal administration of PT-141, a cyclic heptapeptide melanocortin analog, was studied in healthy male subjects and Viagra-responsive erectile dysfunction (ED) patients. RigiScanTM was used to assess erectile response in healthy subjects without visual sexual stimulation (VSS) and in Viagra®-responsive ED patients with VSS. Mean Cmax and AUC(0–t) increased dose-dependently in healthy subjects. Tmax was 0.50 h on average, and t1/2 ranged from 1.85 to 2.09 h. At doses greater than 7 mg, an erectile response induced by PT-141 administration was statistically significant when compared to placebo, with the first erection occurring in approximately 30 minutes. In both studies, PT-141 was administered safely and was well tolerated.

 There was no maximum-tolerated dose identified. Flushing and nausea were the most commonly reported adverse events in both studies, and there were no clinically significant changes in vital signs, laboratory tests, ECGs, or physical exams. PT-141 is a promising candidate for further evaluation as a treatment for male ED based on its erectogenic potential and tolerability profile.

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Study and Development

PT-141 is a non-selective agonist of melanocortin receptors, primarily melanocortin receptors 3 and 4 (MC3 & MC4), with the exception of melanocortin receptor 2 (MC2 – the ACTH receptor). Its bioavailability after subcutaneous injection is approximately 100%, maximal levels occur after approximately 1 hour, with a range of 0.5 to 1.0 hours, and plasma protein binding of PT-141 is approximately 21%.

PT-141 (Bremelanotide) is metabolized via peptide bond hydrolysis; its elimination half-life is approximately 2.7 hours (range: 1.9 to 4.0 hours), and it is excreted from the body 64.8 percent in urine and 22.8 percent in feces. PT-141 (Bremelanotide) causes sexual arousal in both men and women within minutes of administration and has been shown to have significant results on male test patients in the form of intense and frequent erections lasting 2-6 hours. Following each dose, it may cause a temporary increase in blood pressure and a decrease in heart rate.

PT-141 is considered contraindicated in people with uncontrolled high blood pressure or cardiovascular disease due to its blood pressure effects (generally a transient increase in systolic blood pressure by 6 mmHg and diastolic blood pressure by 3 mmHg). As long as PT-141 is not used more than once in a single day, it is not expected to cause more severe blood pressure increases. It has no meaningful interaction with alcohol (unlike flibanserin for which the interaction with alcohol is a major barrier to its use). PT-141 has not been shown to have any negative effects on fertility in animal studies, even at high doses.

Erectile function is the result of a coordinated interaction of the vascular, endocrine, and nervous systems, which results in cGMP-mediated increased blood flow to the penis, a concomitant decrease in venous outflow, and the production of an erection. Erectile dysfunction (ED) is defined as the inability to achieve or maintain a penile erection sufficient to allow satisfactory sexual intercourse. It can be caused by psychogenic, vascular, and/or neurogenic disorders. According to estimates, ED affects 10 to 30 million men in the United States and more than 140 million men worldwide.

The goal of ED treatment is to produce an erection that is strong enough for vaginal penetration and lasts long enough to satisfy both the subject and the partner. Sildenafil (Viagra®), an inhibitor of the type-V cGMP-specific phosphodiesterase, is the most commonly used pharmacological treatment for ED today (PDE5). Sildenafil promotes erections by inhibiting the natural catabolism of cGMP.5 Depending on the etiology and severity of the ED, patients report success rates ranging from 48 to 70%.6 Side effects such as headache, flushing, and changes in color vision are among the reasons for discontinuation of use. Because the combination of sildenafil and organic nitrates increases hypotension, sildenafil is contraindicated in patients taking organic nitrates.


1. Increase in Libido

A study on premenopausal women with sexual arousal disorder found that PT 141 causes a moderate to high increase in sexual desire or libido. All of the study’s participants who had sex within 24 hours of taking PT 141 were satisfied with the overall experience.

According to double-blind studies, the vast majority of patients who take PT 141 as a replacement for ED medications like Cialis or hormone replacement therapy has increased sexual activity.

2. Enhances Mood

How did you feel following your PT 141 treatment? This was the question that researchers posed to participants in their first-ever human trial. The responses –’very good’; ‘younger and more energetic’ – confirmed what has since become widely known: PT 141 improves mood.

Those suffering from hypoactive sexual desire disorder (very low libido) may also have other nervous system issues that PT 141 can treat. PT 141, when administered subcutaneously, can increase dopamine and thus improve mood by acting on melanocortin receptors. Consider combining PT 141 with a nootropic such as phenibut for an even stronger mood boost.

3. Better Quality Sex

Given that it helps you get in the mood, achieve an erection quickly, and keep it for a long time, it’s no surprise that PT 141 helps you have better sex. After all, this synthetic chemical works its magic on both your brain and your body to keep you at your best in bed.

In most clinical trials, patients who received PT 141 medication in doses greater than 1.5mg experienced an increase in blood pressure to the penis, improving sexual activity, sexual desire, sexual arousal, and symptoms of sexual dysfunction and erectile dysfunction. To put it another way, PT 141 is a fantastic way to improve your sexual performance in bed.

4. Boost Sexual Arousal

PT 141, in addition to improving sex, can help increase sexual activity by increasing systolic and diastolic blood pressure, which will pump more blood into the penis.

PT 141 accomplishes this by acting on the central nervous system, which sends a signal to the vascular system to increase blood flow. As a result, most PT 141 users report stronger penile erections, increased sexual satisfaction, and increased sexual behavior. Consider combining PT 141 with Male Extra or Testogen for a more powerful erection and increased sexual activity.

5. Improvement in Sexual Dysfunction 

While PT 141 is not an FDA-approved treatment for erectile dysfunction and is still being studied, most anecdotal evidence and existing clinical research suggest that PT 141 may improve sexual activity and sexual function by acting on melanocortin receptors and improving the vascular system, which increases blood flow to the penis.

Even healthy males experienced libido-boosting effects and an improvement in premature ejaculation in placebo-controlled evaluations and clinical studies. More research on PT 141 and its ability to improve sexual function should be conducted, but the current research is very promising.

Side Effects

Injections of PT 141 have varied effects on different people. At the injection site, you may notice pain, redness, or bumps. Fortunately, the half-life isn’t very long, thus any negative effects will fade in 12-24 hours.

These symptoms will fade in a matter of minutes, so don’t be concerned. Consult a healthcare professional if these symptoms persist. Clinical research have revealed that the following were the most commonly reported negative effects:

  • Nausea 
  • Flushing, redness in face 
  • Pain, irritation or itching at the site of injection 
  • Headache 
  • Vomiting 
  • Cough 
  • Fatigue 
  • Hot flushes 
  • Paresthesia 
  • Dizziness 

PT -141 for Men & Women

Within 21 days of receiving study medication, subjects in both studies underwent a complete medical history, physical examination, clinical laboratory tests (including chemistry, hematology, urinalysis, and urine drug screen), and a resting 12-lead ECG.

In the Phase 1 Study, eligible subjects were healthy males between the ages of 18 and 45, who were within 20% of their ideal weight and had no history of ED, penile abnormalities, or other clinically significant abnormalities. In the Phase 2A Study, eligible patients were adult males between the ages of 18 and 65 who had a diagnosis of ED and had been successfully treated with Viagra® within the previous 6 months, and were current users of Viagra® at the time of enrollment. For this study, successful treatment with Viagra® was defined as achieving an erection sufficient for vaginal penetration 50% of the time while taking Viagra®.

These criteria ensured that patients were physiologically capable of erectile activity at the time of study enrollment. Individual patients’ etiologies of ED were not defined. ED caused by untreated endocrine disease, anatomic deformations of the penis, prostatic disorders, or evidence of clinically significant hepatic, renal, cardiovascular, psychiatric, or CNS disease, including stroke or spinal cord injury, were all exclusion criteria.

Prior to the enrollment of research subjects, a human ethics committee approved the study protocol and informed consent document for each study, and all volunteers provided written informed consent prior to their participation in the study. To ensure adherence to Good Clinical Practice standards and regulatory requirements, both studies were conducted in accordance with a written protocol and applicable FDA regulations and ICH guidelines.

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The dosage of PT 141 will vary depending on the person. Always seek medical advice or follow the guidelines on the label. Your present medical condition will determine the number of dosages you take each day and the period between them.

The following is a dosing guideline for PT 141 that has been suggested by users:

Adults: 1.75 mg injected 45 minutes before sex under the thigh or abdominal skin. Once every 24 hours, use only one injection. No more than 8 injections each month are recommended.


What conditions can PT 141 help men with?

Premature ejaculation, impotence, and erectile dysfunction can all be effectively treated with PT 141 in men.

Is PT 141 going to make me tan?

Unlike Melanotan 2, PT-141 does not significantly increase melanogenesis (pigment development).

Does PT-141 increase sexual desire in both men and women?

YES: PT-141 Bremelanotide boosts both men and women’s sexual drive.

How long does PT 141 stay active in the body?

The effects of PT-141 Bremelanotide can be felt up to 12 hours after administration and can persist up to 3 days, reducing with each passing day.

What is the maximum number of times I can utilize PT 141?

The injections should only be used once every 24 hours and no more than 8 times each month, according to the manufacturer.

Is it safe for me to take PT-141 if I have high blood pressure?

If you have high blood pressure, you should not use PT-141 Bremelanotide peptides.

What causes PT-141 facial redness?

Yes, temporary flushing and redness of the face is a relatively common side effect of PT-141 administration (20.3 percent reported in clinical studies)


PT 141 has the potential to be a successful treatment for sexual dysfunction. Several studies have indicated that a single subcutaneous injection can help treat female sexual arousal disorder, provide longer-lasting erections, and boost sexual enthusiasm. Overall, PT 141 can assist the user in leading a healthy sexual life.

Your doctor should first determine whether PT 141 treatment is appropriate for your ED condition. Please notify the healthcare provider of any medications you have been taking prior to the start of treatment. Subcutaneous injections of PT 141 are administered in areas with fat deposits, such as the lower right side of your abdomen. To ensure the best results, the injection is usually given 45 minutes before the scheduled time.

Doses of the drug vary depending on the user, with some receiving less than 0.1ml/1mg and others receiving more than 0.4ml/4mg. Because it improves mood and desire, the treatment has been shown to be more effective than Viagra.

The final advantage is deserving of your attention. That’s because PT 141 achieves something Viagra, its immediate competitor, can’t: it helps you achieve sexual excitement. As a result, it appears to be a promising treatment for hypoactive sexual drive disorder and erectile dysfunction.

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The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.