S23 Ultimate Guide: Dosage, Side Effects, Benefits

 »  »  S23 Ultimate Guide: Dosage, Side Effects, Benefits

  1. What is S23?
  2. How Does It Work?
  3. Who Uses S23?
  4. Study and Development
  5. Benefits
  6. Side Effects
  7. S23 Stack
  8. Injectable vs. Oral
  9. Dosage
  10. FAQ (Frequently Asked Questions)
  11. Conclusion

Are you considering taking SARMs? S23 can help you get the results you want at the gym if you’re frustrated with your current results.

SARMs aren’t steroid-like substances. These substances are selective androgen receptor modulators, which means they only affect androgen receptors. As a result, you won’t have to worry about the estrogenic side effects that come with anabolic androgenic steroids (AAS).

S23 is one of the more powerful SARMs, and it’s not for beginners or inexperienced users. A cycle of S23, on the other hand, can take you on a crazy ride spanning six to twelve weeks if you have some expertise with these chemicals.

Knowing how to use the right doses on a cycle can help you get the most out of your experience. We’ll go over everything you need to know about constructing the ideal S23 cycle in this post. We’ve created cycle notes for both beginners and intermediate users, as well as PCT suggestions.

What is S23?

S23 is a selective androgen receptor modulator, a novel family of medicines (SARM). SARMs work by attaching to hormone receptors in specific regions of the body to mimic testosterone.

S23, like testosterone and other SARMs, is thought to target muscle and bone tissues in order to stimulate muscular growth and bone health. S23 was shown to shrink the prostate in animal experiments, according to several sites. Clinical investigations, on the other hand, are absolutely insufficient to support any of these assertions.

The “SARMs selectivity idea” may be utterly untrue in reality. It’s never been demonstrated, and SARMs like S23 have never been put through rigorous clinical testing. SARMs could prove to be even more harmful than originally assumed.

In the bodybuilding scene, S23 is becoming increasingly popular. It helps you gain muscle and lose fat while having very few negative side effects. S23, on the other hand, can reduce testosterone levels, necessitating the use of prohibited post-cycle treatment.

The potential for this SARM to be employed as a male birth control has piqued curiosity. S23 caused infertility in rats in 100 percent of cases. The caused infertility was just transient and may be reversed totally once the medicine was stopped.

S23 has been studied to see if it can help women become more sexually motivated. Preventing muscle loss and boosting bone density are two further possible applications. Currently, all SARMs are banned in professional sports by the World Anti-Doping Agency.

How Does It Work?

SARMs are thought to bind to androgen receptors in the muscles and bones while having only a little effect on the prostate and other tissues. SARMs with varying degrees of selectivity are thought to exist (based on their chemical structure). In humans, their selection has never been demonstrated.

S23 forms highly strong interactions with androgen receptors, making it one of the most effective SARMs currently available, according to cell research.

S23 has a complicated effect on muscles and bones. When a SARM binds to an androgen receptor, it stimulates the activity of genes involved in the production of muscle proteins. Activated receptors can also convey signals to bone-building cells, causing them to become more active.

S23’s contraceptive effects are related to its ability to inhibit FSH and LH, two important hormones for sperm production. At higher doses, however, this effect vanishes.

S23 has a half-life of 11.9 hours in male rats. S23 is absorbed 96 percent when taken by mouth, and levels peak after about 4 hours. Its human absorption is unknown.

Who Uses S23?

SARMs are incredibly appealing appearance enhancers without the downsides of steroids. S23 is no exception, as it is widely regarded as one of the most powerful SARMs available. In bodybuilding competitions, S23 is utilized to achieve a chiseled, harder look. To produce a competitive physique, it is common practice to add S23 near the end of the training cycle.

Stacking S23 with other SARMs has been reported by some users. Stacking unapproved medications (such as S23 and other SARMs) is a risky practice. Because the effects, side effects, and combinations of these medications have not been studied, there is an increased risk of damage. Even more uncertain are the long-term dangers.

Study and Development

In castrated male rats, S-23 was discovered to be a powerful and effective SARM with much higher anabolic activity than androgenic activity. S-23 with EB showed promise for hormonal male contraception in intact male rats. In rats given EB with 0.1 mg/d S-23, either no sperm or very low sperm counts in the testis were successfully obtained, and a 100 percent infertility rate was recorded in the efficacy study. 

Unlike testosterone, which had biphasic effects in the testis and epididymides and nonselective increases in the peripheral reproductive tracts (such as the prostate and seminal vesicles), S-23 had solely biphasic effects in the organs indicated. S-23 also enhanced the weight of the levator ani muscle while decreasing the amount of FM.

Serum hormones and sperm counts returned to normal following therapy, resulting in 100% pregnancy rates. These findings suggest that S-23’s influence on spermatogenesis is totally reversible. This is the first study to indicate that by utilizing an EB-SARM combination therapy to preserve libido without impacting quantitative spermatogenesis, no sperm in the testis may be produced. 

This treatment reduced the weights of the prostate, seminal vesicles, testis, and epdidymides while retaining muscle mass, fat-free mass percentage, and BMD. In a separate PK investigation, S-23 was found to have a high oral bioavailability (96 percent ). The discovery of a SARM with these promising pharmacologic and pharmacokinetic properties is a significant step toward the male pill, but there is still much work to be done.


S23 has been shown in cell experiments to form strong interactions with androgen receptors, making it one of the most potent SARMs available. You can expect to reap the following benefits as a result of these “strong bonds”:

Increase in lean muscular mass

Rats were administered S23 combined with estrogen to stimulate mating (which can cause muscle loss). S23 was able to counteract the effects of estrogen, allowing the rats to gain lean muscle mass and strength instead. S23 users have also noted that they were able to keep their gains longer at the end of their cycle.

Increased stamina and strength

After introducing S23 into their cycle, users have reported considerable increases in physical endurance, speed, and stamina. As a result, individuals were able to exercise harder and for longer periods of time.

Loss of weight

S23 SARM was found to reduce average body weight and fat mass while enhancing bone mineral density and muscle size in rats in a research. This study also found that high doses of S23 can boost fat burning and oxidation, resulting in significant weight loss. As a result, it comes to reason that the more S23 you take, the more fat you’ll lose.

Muscle wasting is avoided

S23 assisted rats in not losing muscle mass as a result of glucocorticoids (during a study) (used long term, glucocorticoids can cause serious muscle loss). S23 prevented the overuse of glucocorticoids from reducing the size of fast-twitch (power) and slow-twitch (endurance) muscles.

Male contraception

Given that condoms aren’t 100 percent efficient at preventing pregnancy, it’s no surprise that researchers are seeking for new ways to keep men from getting pregnant. S23, on the other hand, has shown promise as a potential ‘male pill,’ as it is said to decrease the hormones FSH and LH, both of which are necessary for sperm production. 

Bone strength is improved

S23’s dual action effects of activating bone-building cells and enhancing muscle strength may be able to increase bone strength when combined. S23 SARM, for example, has been shown in animal experiments to increase bone mineral density and muscle mass. As a result, S23 may be able to aid postmenopausal women and osteoporosis patients who have developed bone damage as a result of low estrogen levels. S23 can help maintain your bones strong and healthy by mimicking testosterone and speeding up recovery and preventing fractures (by increasing muscle mass).

Female sexual motivation is boosted 

It is normal for women to feel a decline in sexual desire and arousal after menopause (due to natural decreases in sex hormones). Normally, testosterone is used to address a lack of sexual motivation (HSDD); however, this can lead to other issues such as an increased risk of heart disease and breast cancer. S23 can help you to experience a positive boost in sexual desire with none of the risks commonly associated with testosterone. 

Minimal to no water retention

Users have reported experiencing no bloating/water retention whilst using S23, meaning they were able to maintain all of their gains even after their S23 cycle had finished. As a result, S23 is regularly used for cutting by bodybuilders and athletes.

Harder muscle aesthetic

If you’re training for a competition, then S23 could help you to develop a harder, grainier muscle aesthetic (as it encourages you to develop dry, lean-looking muscles).

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Side Effects

​​While this SARM is much safer than anabolic steroids, it isn’t without flaws. S23, like many other powerful SARMs, has been related to the following negative side effects:

  • Testosterone deficiency
  • Aggression
  • Shrinking of the testicles
  • Night Sweats
  • Urine that is darker
  • Hair loss is a common problem

S23 Stack

PPAR agonists and other protein agonists such as SR9009 and Cardarine are excellent options. Another common option for raising HGH levels during your cycle is MK-677. SARMs aren’t present in any of these medications. They can, however, be useful for post-cycle support and PCT for a speedier recovery.

S23 is a powerful chemical that can help you gain muscle on its own. When combined with other fat-burning chemicals like Ostarine (MK- 2866) and LGD 4033, it can help you maintain lean muscle mass while cutting.

Injectable vs Oral

One of the key advantages of injectable S23 over its oral cousin is that it is more powerful. Based solely on bioavailability, a 50 mg oral dose of S23 has the same impact as a 30 mg injection of S23. The injectables are far more powerful. Furthermore, based solely on the dosage quantity, the number of possible side effects from the prescription can be reduced without surrendering any of the drug’s benefits. The amount of S3 in the dosage has no bearing on the outcome. It’s critical that their calorie intake and workout correspond to the amount of S3 they’re taking.

Watch the video below to get a full insider scoop from none other than Dr. Tony Huge! S23 is undoubtedly one of the strongest SARMs in development right now.


Establishing your dose is the first step in creating your optimum S23 cycle. Beginners and advanced users require varying doses, therefore we created some broad guidelines for both.

It’s also worth noting that in mouse studies, S23 has a 12-hour half-life. While estimating what that would be in human terms is difficult, splitting your S23 dose is a safe method. One-half of the dose should be taken in the morning and the other before night or training.

S23 Dosage for Beginners (8-Week Cycle)

From week one to week two, take 5mg each day.

5mg every day from Week 3 to Week 6.

Weeks 7–8 – 15 mg per day (optional)

S23 Advanced Dosage (12-Week Cycle)

From week one to week two, take 10mg each day.

15mg every day from Week 3 to Week 6.

Weeks 7 and 8: 20 mg per day

30mg every day from Week 9 to Week 12.

Both cutting and bulking cycles can benefit from these dosages. If you’re already slim when you start your cycle, you’ll notice that you lose weight while gaining muscle, as long as you don’t overeat.


Is there anything I can do to help my liver during my S23 cycle?

For S23 cycles, I recommend taking a liver support supplement including Milk Thistle. It has been shown to increase the levels of markers that signal liver stress. These effects, however, are only transient and rarely result in any physical negative effects.

Is an Aromatase Inhibitor (AI) required for my S23 Cycle?

No. On the body, S23 has no aromatase activity. As a result, it lacks the estrogenic properties of AAS. S23’s androgenic activity has an anti-estrogenic effect on estrogen levels. Increased androgenic activity aids in the reduction of estrogen, but gyno is still a possibility.

Why is S23 a prohibited substance?

S23 is presently in pre-clinical testing and has yet to receive FDA approval. As a result, S23 and SARMs are still considered “research compounds” and are not suitable for human ingestion.


S23 is a potent SARM and one of the most potent chemicals on the market. Stronger chemicals, on the other hand, carry the danger of negative effects. S23 has more sides than other SARMs, and in order to plan a good cycle, you must first grasp the drug’s mechanism and how it works in your body.

When using this product, follow the dosage guidelines and don’t exceed the daily dosage limitations based on your level of experience. S23 is not the best initial compound for a SARMs cycle, and beginners should instead look into RAD 140 or LGD 4033 as an introduction to SARMs.

S23 may have an inhibitory effect on the HPTA. As a result, it’s a good idea to see a doctor about your bloodwork following a cycle. Some people simply need a moderate PCT with over-the-counter medications, while others may need a pharmaceutical PCT.

S23 is a great cutting stack, with an effect equivalent to other anabolics like Anavar and Winstrol V. Users should not increase their dose or cycle length, and should follow the rules outlined in this article.

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The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.