S4 (Andarine) Complete Guide: Benefits, Side Effects, Dosage

 »  »  S4 (Andarine) Complete Guide: Benefits, Side Effects, Dosage


  1. What is Andarine?
  2. How Does It Work?
  3. Who Uses Andarine?
  4. Study & Development
  5. Benefits
  6. Side Effects
  7. Bulking and Stacking Andarine
  8. Dosage
  9. FAQ (Frequently Asked Questions)
  10. Conclusion

Andarine S4, a SARM substance, is the most popular among bodybuilders during the Cutting Phase. Andarine is one of the most dynamic and effective (if not the most powerful) products for mass body fat loss with quick apparent results. Andarine S4 is currently produced by GTX Pharmaceuticals and is solely available for medical/therapeutic use (and more specifically for fighting muscle atrophy or osteoporosis).

Andarine binds to androgen receptors, which are proteins in the body. Andarine attaches to these receptors and signals the body’s muscles and bones to grow. Andarine does not appear to have as many negative effects in other parts of the body as some other drugs that bind to androgen receptors, such as steroids.

What is Andarine?

Andarine, also known as S-4, S-40503, or 8, is a selective androgen receptor modulator (SARM) that was created to treat osteoporosis and muscle wasting. SARMs (selective androgen receptor modulators) are medicines that bind to the androgen receptor (AR), the hormone testosterone’s major site of action.

Andarine was once thought to be the ideal SARM because of its excellent oral bioavailability and muscle- and bone-building properties (studied in animals).

The drug’s phase I human trials were supposedly successful, but no studies have been published. However, further research of the drug was shelved in favor of Ostarine, a similar-looking SARM also known as S-22.

This was most likely due to Andarine’s poor safety record. It caused vision-related negative effects, which adds to the extensive list of reasons why this medicine should never be taken.

How Does It Work?

Andarine mimics the actions of testosterone since it has a high affinity for the androgen receptor (AR). Muscles and bones, on the other hand, are far more affected than reproductive organs. That’s why it’s thought that Andarine and other SARMs have fewer adverse effects than anabolic steroids.

Bodybuilders often use this unproven idea as “evidence” that taking SARMs will not result in significant testosterone suppression or increased estrogen levels. This, however, is not the case.

The “SARMs selectivity idea” may be utterly untrue in reality. It’s never been demonstrated, and SARMs like Andarine and Ostarine have never been put through rigorous clinical testing. SARMs could prove to be even more harmful than originally assumed.

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Who Uses Andarine?

People take Andarine to boost sports performance and to treat problems including involuntary weight loss in the terminally ill (cachexia or wasting syndrome), osteoporosis, and prostate health, however, there is no scientific evidence to back up these claims. It’s also possible that Andarine is harmful.

Although most drugs, such as Andarine S4, were designed for medical purposes, they are now primarily utilized for sports (even illegally). SARM S4 (also known as Andarine) was developed specifically to combat diseases and medical disorders such as:

  • Osteoporosis
  • sarcopenia sarcopenia sarcopenia (loss of muscle mass due to aging )
  • BPH (Benign Prostatic Hyperplasia) is the swelling or hyperplasia of the prostate.
  • prostate cancer is a type of cancer that affects
  • Cachexia
  • Syndrome of Wasting

Study and Development

The effects of Andarine S-4 in the skeletal muscles, bones, and pituitary glands of castrated male rats were studied in a 2005 scientific study. Animals were administered with Andarine, dihydrotestosterone (DHT), or vehicle for 8 weeks after castration.

Andarine returned soleus muscle mass and strength to intact animals, as well as levator ani muscle mass. Animals treated with DHT (3 mg/kg) showed similar alterations. DHT (3 mg/kg) increased prostate and seminal vesicle weights more than 2-fold higher than undamaged controls, although Andarine reverted these androgenic organs to just 16 and 17 percent of control levels, respectively, compared to the anabolic benefits seen in muscle. Castration-induced lean body mass loss was reversed with the use of andarine and DHT.

Furthermore, Andarine therapy increased total body bone mineral density much more than DHT. In castrated rats, andarine S-4 showed agonist activity in the pituitary and dramatically reduced plasma LH and FSH levels in a dose-dependent manner. In conclusion, Andarine S-4 produced robust anabolic effects in skeletal muscle, bone, and pituitary with minimal pharmacologic effect in the prostate.

Another scientific investigation looked into the skeletal consequences of Andarine S-4 on osteopenic rats. On the first day, aged female rats were gonadectomized or sham operated and divided into treatment groups. Dosing began on day 90 and continued every day until day 210. Dual energy x-ray absorptiometry was used to estimate whole animal bone mineral density (BMD), body weight, and fat mass (DEXA). DEXA or computed tomography were used to examine the regional anatomy of the removed bones. Three-point bending was used to assess femur strength. Andarine increased the BMD of the total body and the lumbar vertebrae (L5-L6) to that of healthy controls. At the femoral midshaft, significant improvements in cortical bone quality were detected, resulting in higher load bearing capability.

Andarine showed partial/complete bone parameter recovery to age-matched intact levels. Increased efficacy in cortical bone areas is consistent with androgen activity in bone, as reported. Andarine’s potential to enhance bone anabolism, reduce bone resorption, and increase skeletal muscle mass/strength has indicated that it may be especially effective in osteoporosis, and SARMs are promising new options for treating osteoporosis in general.

Because it can competely prevent the binding of Dihydrotestosterone (DHT) to its receptor sites in the prostate gland, andarine S-4 may be effective in the treatment of benign prostatic hyperplasia (BPH). Andarine has an advantage over typical antiandrogens for the treatment of benign prostatic hyperplasia in that it prevents the negative effects that antiandrogens often cause by acting as a partial agonist on the androgen receptor (AR).

A noncancerous increase in the size of the prostate gland is known as benign prostatic hyperplasia (sometimes known as benign prostatic hypertrophy or simply BPH). The enzyme 5-alpha-reductase type II in the prostate gland converts circulating testosterone to DHT, which acts locally rather than systemically. DHT then attaches to androgen receptors in the nucleus of cells, perhaps causing BPH.

Frequent urination, difficulty starting to urinate, a weak stream, inability to urinate, or lack of bladder control are all possible symptoms. Urinary tract infections, bladder stones, and chronic kidney disease are all possible complications.


The short and long-term effects of this SARM have yet to be fully discovered because it is currently an experimental medication. The following effects and benefits are based on the most recent research and personal experiences.

Muscle Growth Is Promoted

The ability of andarine to stimulate the androgen receptor (AR) in rats has been demonstrated. S4 has a high binding affinity for the AR without causing considerable suppression, according to a study. It also had a higher anabolic ratio in rats than normal testosterone.

Muscle Strength Improved

There have been instances of persons improving muscle strength and general performance as a result of increased AR activation and muscle hypertrophy. There have been reports of persons gaining 20 pounds on their bench press after using Andarine. These increases are dose-dependent, but they can also be influenced by how you react to the substance.

Properties For Burning Fat

S4 was discovered to have fat-burning capabilities in a study. While there isn’t a lot of information, it does reveal some interesting facts. S4-treated rats developed muscular mass and bone density while reducing body fat in this study. Some suggest that it’s due of the increased muscle mass, which leads to a higher metabolic rate.

May Help to Strengthen Bones and Fight Osteoporosis

Andarine improved bone mineral density and strength in castrated male rats as well as female rats who had their ovaries removed (this is a commonly used animal model of osteoporosis). Andarine may be especially effective in osteoporosis since it enhances muscle strength as well as bone density, potentially lowering the incidence of falls and fractures.

“I experienced vision side effects from oral S4. Even low dosages caused vision side effects. I’m not a fan of oral S4, especially at high dosages.

I have gone up to 150mg/day with injectable S4 with no vision side effects. It really dried out and hardened my physiques. My veins came out like crazy. Similar results to Winstrol. I recommended dosages of 50-100mg/day for men. At low dosages, it’s great for women. I recommend dosages of 10-25md/day for women. Women start to get side effects at dosages of about 50mg/day.

S4 has a short half-life so it’s something you would add into a stack instead of using it as the primary drug of choice.”


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Side Effects

While there is no clinical research on the adverse effects of Andarine on humans, there is a sufficient quantity of anecdotal user data we may learn from. In addition, by looking at the negative effects reported in animal studies, we can assess the potential side effects of Andarine on humans. Here are some of Andarine’s possible adverse effects:

  • Testosterone Deficiency
  • Having Trouble Seeing At Night
  • Toxicity of the Liver in a Mild Form
  • HDL cholesterol levels have dropped.
  • Hair Loss that is Slightly Accelerated (Use RU58841 for This)
  • Some users may experience more side effects than others, while others may have none at all—reports on this vary greatly.

However, most recreational users report that the more severe adverse effects fade away quickly after stopping Andarine use.

Bulking and Stacking Andarine

Some users choose to take many SARMs at the same time, known as a SARMs stack, in order to achieve faster results and improve performance even more. Andarine is best used for cutting, which is why it’s often combined with other cutting SARMs like Cardarine or Ostarine by recreational users.

Bulking Stack Example

25 milligrams of andarine each day

20 mg Ligandrol each day

10 mg of YK11 per day

Stack of Cutting Example

50 mg of andarine each day

20 mg of cardarine each day

25 mg of ostarine each day

While Andarine (S4) is more suited to cutting, it can also be utilized as part of a bulking stack to keep you lean and prevent fat spillover.


The right dose of andarine is determined by a variety of factors, including the user’s age, health, and other circumstances. There is currently insufficient scientific evidence to define an optimal dosing range for andarine. Keep in mind that natural products aren’t always safe, and that dosages are crucial. Before using, be sure to read the product label and consult your pharmacist, physician, or other healthcare expert. Nonetheless, the following is some dosing information:

  • Beginner Dose: 25 mg per day
  • Intermediate Dose: 50 mg per day
  • Advanced Dose: 100 mg per day

Because Andarine has a 4-hour half-life, most users spread their doses out throughout the day to maintain an even blood concentration.


Is Adarine legal?

Until now, the FDA has not approved any other non-medical uses for this product. Even therapeutic use of Andarine S4 necessitates a specific prescription and ongoing medical supervision. Despite the clear ban, many bodybuilders utilize this potent drug for athletic purposes.

Will I be eligible for any sporting benefits, and if so, which ones?

Yes. Andarine S4 is a highly effective substance that provides immediate physical benefits to the consumer. It is well known for its application in cutting cycles (Cutting Cycles), but it also ensures similarly dramatic results in reinforcement cycles (Reinforcement Cycles) (Bulking Cycles). Although many people are familiar with S4 as a fat-burning and fat-mass-loss enhancer, it can also be utilized during the muscle-rebuilding phase.

Is it possible for SARM S4 to have adverse effects or interactions?

We need to clarify one thing before listing some of the negative effects and probable interactions of SARM Andarine S4 (particularly if used frequently and for a long time to improve sports performance).

Is Andarine linked to gynecomastia?

Because andarine does not interact with aromatase enzymes, it does not produce gynecomastia.

Is there a link between andarine and cortisol production?

Andarine has no effect on cortisol levels in the body and does not boost its production.

Is Andarine a prohibited substance in sports?

Yes, Andarine is on the World Anti-Doping Agency’s (WADA) “Prohibited List” as an S1 Anabolic Agent.

Is Andarine a testosterone booster?

Andarine may diminish natural Testosterone levels and restrict production, however, it does so at a far lower rate than some anabolic steroids. The size of the dose and the length of time it is used have an impact on the lowering of testosterone production.


Andarine is a selective androgen receptor modulator (SARM) that was found as one of the earliest SARMs. Because the study has been halted, no new clinical data will be accessible. It has been demonstrated in studies to improve performance, general muscular mass, and fat-burning abilities.

There are several serious side effects associated with this SARM that you should be aware of. Because of its suppressive effects, using a post-cycle therapy is strongly recommended. As part of a fat-burning and muscle-building protocol, many people use it with Ostarine.

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“More men’s physique competitors have won competitions using only S4 than any other compound. It appears to be an adequate replacement for steroids in amateur physique divisions.

I personally don’t like it because even though the vision side effects are mild and temporary, I can’t afford any vision compromise because I’m constantly on my phone. It appears that the vision side effects and benefits are directly related to the dosage and duration of a cycle. Men seem to get great benefits from longer cycles at 50mg/day, or short cycles at 75-100mg/day. We also have had a lot of female competitors who have won physique competitions using only 25-50mg/day. Which is surprisingly close to a man’s dosage, but they experienced no virilization side effects.

S4 gives a dry hard look to the muscles and maintains performance while dieting. I defiantly recommend cycling off because of the vision side effect. I personally like running a higher dosage for a short period of time before side effects accumulate.”



The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.