Semax All You Need to Know: Dosage, Benefits, and Side Effects

 »  »  Semax All You Need to Know: Dosage, Benefits, and Side Effects

  1. What is Semax?
  2. How Does Semax Work?
  3. Who Uses Semax?
  4. Study and Development
  5. Semax vs Selank
  6. Semax and BAC (Bacteriostatic Water)
  7. Benefits
  8. Side Effects
  9. Dosage
  10. FAQ (Frequently Asked Questions)
  11. Conclusion

Semax was created in the 1980s in Russia. Initially, it was intended to prevent and cure circulation problems like strokes, heart attacks, and excessive blood pressure. The drug was so successful that its creators were awarded the Russian Federation’s Government Prize in 2001.

Several small-size human experiments have been done throughout the years to investigate its ‘nootropic’ or ‘cognitive boosting’ potential. This is due to the effects of the peptide Semax on carboxypeptidase, an enzyme that performs a variety of important activities in the brain and body of humans.

What is Semax?

Unlike PT 141, Semax is a neuropeptide. It was first used to treat circulation problems like heart attacks, high blood pressure, and strokes. However, its link to the adrenocorticotropic hormone (from which it is derived) has boosted its reputation as a cognitive enhancer over time.

ACTH regulates the body’s synthesis of cortisol, also known as the stress hormone. This gives it the ability to alter our mental capacities and how people react in stressful situations. It also allows ACTH, and hence Semax, to control our memory, focus, and mood.

Another unique feature of traditional Semax is that it increases our motivation. It also helps people get a handle on tendencies like procrastination and avoidance by priming our brain. Semax also generates a controlled state of mental tension in times when people need to be more aware.

In addition to everything else, this experimental medicine aids in the reduction of pain in the body. As a result, it is able to reduce inflammation while also increasing immune cell activity.

How Does Semax Work?

Semax works by chemically stimulating the hippocampus, limbic reticular complex, and a number of receptors in the brain. Semax stimulates the release of brain-derived neurotrophic factor due to its impact on receptors (BDNF). This is when things start to get interesting.

The neuronal survival factor BDNF is responsible for. It extends the life of your nerve cells by assisting them in the growth, maintenance, and mutation processes. This protein is also involved in the regulation of synaptic plasticity, which is important for memory and learning. 

Long-term stress has been demonstrated in several studies to lower BDNF levels in the brain. Researchers have concluded that a decrease in BDNF levels is linked to depression, aging, and PTSD, all of which Semax helps to prevent by promoting the production of these neurotrophic substances.

Semax has also been proven to reduce enkephalin breakdown. Enkephalins are peptides that are found in nature and are responsible for lowering pain in the body. Their levels must be in equilibrium for optimal brain health.

Who Uses Semax?

Semax can be used in many ways by a lot of people. Usually this medication is used by people to treat the following conditions that they suffer from:

  • Anxiety
  • Memory Loss
  • Ischemia Attacks
  • Stroke
  • Loss Of Nerves
  • ADHD
  • Withdrawal From Opioids
  • ALS
  • Parkinson’s Disease
  • Alzheimer’s Disease

Study and Development

The goal of the studies was to see how Semax affected learning ability, pain sensitivity, and pain tolerance in white rats given varied doses via intranasal and intraperitoneal methods. Semax possessed nootropic properties. It was investigated in a study based on the learning of the conditioned passive avoidance response to pain stimulations.

Semax showed nootropic and analgesic properties, according to the findings. Intranasal Semax was found to be more effective than i.p. Semax in improving animal learning. Pain sensitivity was unaffected by Semax. All of the findings revealed that multiple brain areas and mechanisms are involved in mediating Semax’s nootropic and analgesic effects.

Semax has an impact on a number of biological processes that are involved in the operation of numerous systems. The immunological response is the process that the medicine has the biggest impact on. Semax increased the expression of genes that code for chemokines and immunoglobulins, as well as genes that regulate the number and movement of immune cells. Semax affects the expression of genes that enhance the establishment and function of the vascular system in rats with localized ischemia in the brain.

The immunomodulatory effect of the peptide revealed in our study, as well as its impact on the vascular system during ischemia, are most likely the fundamental processes driving the peptide’s neuroprotective effects.

Semax VS Selank

Semax and Selank are nearly indistinguishable. Selank is a peptide that is similar to tuftsin, an immune system peptide that can boost several types of immune system-mediated immunity against bacteria, viruses, and cancers. The inclusion of PGP was then supplied to Tuftsin. The remainder of the peptide’s activities on its target receptor are consistently continued by this neurotrophic and neuroprotective antioxidant trimer.

PGP is also included in Semax, and it has some interesting neurotrophic activity-increasing qualities. Semax changed gene expression involved in cell proliferation and migration in the context of experimental localized ischemia. It protects against hemispheric ischemic stroke as well as transient ischemic attack. It has also been discovered to alter gene expression in the immunological and vascular systems.

Selank is more anxiolytic and stress-relieving, but Semax, in addition to its analgesic properties, is more energizing and motivating. Selank may be a superior option for the treatment or decrease of anxiety symptoms, stress, strokes, and depression disorders.

Semax and BAC (Bacteriostatic Water)

Bacteriostatic Water is a prescription treatment that is used to dilute or dissolve drugs and can be used on its own or in combination with other treatments. BAC belongs to the Sterile Irrigating Solutions class of medicines and has a number of negative side effects, including:

  • hives,
  • breathing problems,
  • if your cheeks, lips, tongue, or throat swell,
  • fever,
  • the injection location is infected,
  • Symptoms include leg or groin pain, warmth, and edema, as well as
  • At the injection site, there is redness, warmth, and discomfort.

Some individuals put Semax from Cerotropic in a nasal spray bottle with Bacteriostatic water and use it as a nasal spray. This is mostly due to the scarcity of nasal spray. Bacteriostatic water, on the other hand, is for injections and will burn your nose if used. It has also been demonstrated to aid in the drying of mucus. Semax makes use of ultra-pure, high-quality deionized water. BAC water can be used, but it will burn. The burning is inconvenient, but not dangerous.


Selank and Semax work in the brain as Melanocortin Stimulating Hormone-like Peptides, causing a wide range of effects on brain activity and fitness. Selank is commonly used for anxiolytic characteristics, immunological enhancement, stomach protection, and opiate and alcohol withdrawal/dependence. Here are a few of its benefits:

  1. A boost in motivation

Many people could benefit from a boost in motivation. According to a recent survey, 8% of the world’s population is sufficiently driven to attain their objectives. The others aren’t driven enough to develop habits that will help them achieve their goals. Semax peptide may provide people with a solution to boost our motivation levels. By increasing dopamine, a neurotransmitter involved in reward-driven learning and, hold your breath, motivation, this nasal spray can give you the push you need to reach your goals.

  1. Increased mental acuity

Mental clarity is necessary for attaining your goals and improving your mental health, according to common sense. People who have a clear idea of what they want to achieve are considerably more likely to succeed. They’re also more likely to bounce back from setbacks and learn from their errors. The majority of you are probably already aware of these facts. Semax, on the other hand, enhances mental clarity, which the majority of people are unaware of. It accomplishes this by assisting you in maintaining your composure under duress, ensuring that when the going gets tough, you’ve got what it takes to persevere.

  1. Improved Mood

The COVID-19 epidemic has caused mood swings all around the world, as no one could have predicted. More than a quarter of those polled had signs of or were at risk for a mood disorder, with youth’s mental health taking the brunt of the damage across all age categories. Semax might be able to help people get out of this mental health quagmire. This investigational medication promotes the release of dopamine, a neurotransmitter that governs mood among other things. People take dopamine pills to improve their mood because of its impact on how they feel.

  1. Memory Enhancement

Memory issues are more widespread than you might believe. This is a condition that affects people of all ages, not only those over the age of 65. Memory issues affect roughly 14 percent of younger persons and 22 percent of older adults in the United States, according to population surveys. Semax has shown in human clinical studies that it has the potential to provide a solution to this problem. Healthy men were given intranasal Semax, which successfully increased their operative memory while simultaneously boosting their tolerance to hypoxia (a condition responsible for memory loss).

  1. Improved Circulation of Blood

Blood circulation is essential for good health. Wounds heal faster, the heart stays healthy, and the brain stays sharp when blood flows continually throughout the body. Furthermore, proper blood circulation aids in the nourishment of skin cells by transporting free radicals away. According to clinical studies, Semax gives all of these advantages. This investigational medicine has proven to be effective in the treatment of patients who have poor cerebral blood circulation. Its medication improved the patients’ circumstances, demonstrating that Semax improves blow flow.

  1. It Has the Potential to Treat Depression

Major depression affects 16 million American adults each year, or around 6.7 percent of the population, according to estimates. This figure only includes recorded instances; the true number of people suffering from depression is likely to be significantly higher. That’s the end of the bad news. Semax was found to be beneficial in boosting the action of dopamine and serotonin hormones in the brain in one animal research. Antidepressant effects are recognized for both of these hormones. Semax may aid in the treatment of depression by boosting their levels.

Swiss Chems Semax 30mg

Your ALL-around Reliable Nootropic

CODE “MATRIX10” – 10% discount

Side Effects

Semax is not without its drawbacks. This means that more research will be needed to gain a full picture of the negative impacts Semax can have. Semax should be avoided by anyone with a persistent nervous system problem. Because there isn’t any clinical data on this drug, it’s impossible to say how it will interact with any existing conditions. Patients who are on different medications should follow the same advice.

Hair loss has been observed by a few Semax users. Semax boosts the release of BDNF, which speeds up hair follicle growth and promotes hair loss, according to one complaint. Semax has no negative effects other than infrequent hair loss, making it one of the top nootropics on the market right now.


The Semax dosage is determined on which form of the drug you are taking. It comes in three different forms: n-acetyl Semax (the strongest), n-acetyl Semax Amidate (very bioavailable), and Adamax (new version). The following are the Semax dose recommendations based on user feedback:

  • Between 100 and 900 mcg for the acetyl version
  • Between 200 and 900 mcg for Acetyl-amidate (NASA).
  • Between 50 mcg and 3 mg in the original version

The original, unaltered version comes in 20 mg vials with a dose of 200 mcg of each spray. Effects can be felt with just a single drop. That’s because the original version has the best qualities and stimulates neurotransmitters the best. Keep in mind, however, that they are suggestions from users. Several Semax reviews claim that using this synthetic peptide medicine in the recommended dosage worked for them. If you’re unsure, talk to your doctor before starting to take Semax.

Swiss Chems Semax 30mg
CODE “MATRIX10” – 10% discount


How Quickly Does Tolerance Develop?

With Semax, there’s a built-in reverse tolerance. The longer you take it, the less you will require.

Is It Effective in the Treatment of ADHD?

Yes, Semax can help with ADHD symptoms.

Does It Have an Impact on Cortisol Levels?

Your cortisol levels may be affected by adrenocorticotropic hormone (ACTH).

How long is it going to last?

Users of Semax report a wide range of duration and half-life. Intranasal delivery is a variable to consider because it lasts for a shorter period of time than injections. Approximately 2 to 10 hours.

When Should You Take This Nootropic?

It is meant to be used on a daily basis for clinical and electrophysiological research. Semax from Russia, which has a lower concentration (0.1 percent), is indicated for boosting learning and memory, mood, and brain function, and should be used on a regular basis.

Is Semax legal in the United States?

The FDA has not approved Semax, and it is classified as an “unscheduled drug” in the United States. Unscheduled medications can be purchased without a prescription from a doctor. They can be purchased from any retail location and do not require expert supervision.

Is it necessary to keep Semax refrigerated?

Despite the fact that Semax is a spray, it is safe to travel with and does not require refrigeration once opened. It’s best to store Semax away from light, heat, and moisture to extend its shelf life.


Semax provides a number of desirable features. This neuropeptide can help you become more motivated, boost your intellect, and improve your mental clarity. Semax can also help you enhance blood circulation throughout your body, which has a variety of other advantages.

That’s not all, though. Semax has also been demonstrated to be effective in the treatment of depression. It causes the production of hormones (dopamine and serotonin) that are known to be antidepressants. Anyone who is depressed has an added motivation to take this medication.

Keep in mind, though, that Semax is a prescription-only medication. This indicates that its danger profile isn’t fully understood. Before beginning to take Semax nootropic, consult with your doctor if you have any pre-existing medical conditions or are currently using any supplements.

Swiss Chems Semax 30mg

Start improving how you live your life NOW!

CODE “MATRIX10” – 10% discount


The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.