Sildenafil Full Guide: Benefits, Dosage, and Effects

 »  »  Sildenafil Full Guide: Benefits, Dosage, and Effects


  1. What is Sildenafil?
  2. How Does Sildenafil Work?
  3. Study & Development
  4. Sildenafil for Men & Women
  5. Benefits
  6. Side Effects
  7. Dosage
  8. FAQ (Frequently Asked Questions)
  9. Conclusion

Dr. Tony Huge on Sildenafil

Sildenafil is Viagra and Viagra is Sildenafil.  I use it almost everyday.  Although there are better options like Tadalafil and Vardenafil (Cialis and Levitra) I still use Sildenafil the most because it’s cheap and accessible.  70% of the time I’m using Swisschems, 20% EnhancedRX, and 10% buying it over the counter in Thailand if I don’t have the others on hand.  But the Thailand pharmacy price is much more expensive than Swisschems and they come in 100mg tablets that taste terrible to bite in half and usually I prefer to take 50mg.  I take 50mg of sildenafil usually twice a day.  There is a lot of conflicting information about whether we build a tolerance to it but it is my experience that I do.  So I do have to take breaks so it keeps working.  So I usually take it something like 50mg twice a day for 4 days then take 2 days off and use tadalafil those days but it’s always different.  I usually have sex with 2-3 different girls per day which I wouldn’t be able to do without Sildenafil so for me it’s necessary and worth the risk of side effects from long-term use.  The main side effect from long-term chronic use to be concerned about is vision problems but I don’t suffer from that or any other side effect that I am aware of.  In fact, I was using Peptide Cibinitide ARA 290 and my vision has improved over the last few years despite aging and chronic viagra use.  Maybe a smarter approach for me though would be to use more vardenafil instead of sildenafil for the fewer side effects and more benefits.  I also enjoy the benefit of great muscle pumps at the gym when sildenafil is still in my system.

Erectile dysfunction is a growing concern among men in the past decade! Fortunately, Sildenafil might just do the trick to get the blood flowing to your pecker. This peptide increases circulation for men to achieve an erection. An astonishing two out of every three men always get the same results. 

Sildenafil is also used to treat pulmonary hypertension (high blood pressure in the blood arteries that supply the lungs) (high blood pressure in the blood vessels that supply the lungs). Helping relieve users from various cardiac problems. 

What is Sildenafil?

Sildenafil is a prescription drug. It comes in the form of a tablet and suspension (liquid). Both are taken by mouth. It also comes in an intravenous (IV) form, which is only given by a doctor. Sildenafil oral tablets are available as the brand-name drugs Viagra and Revatio. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Sildenafil typically takes 30 to 60 minutes to work for erectile dysfunction. You can take it up to four hours before having intercourse. Sildenafil does not create erections on its own. It is important to note that the peptide works hand in hand to make arousal easier for you. 

A few studies have also shown how Sildenafil could be a reliable treatment to pulmonary hypertension, as it dilates the blood vessels inside the lungs. 

It is important to note that headaches, nausea, hot flashes, and dizziness are the most prevalent side effects. Many males experience no or only minor side effects. If you also use nitrate drugs, taking sildenafil can be harmful (often given for chest pain). The combination could result in a hazardous drop in blood pressure. Consult your doctor or pharmacist if you’re not sure if you’re taking nitrate.

How Does Sildenafil Work?

Sildenafil belongs to the phosphodiesterase type 5 (PDE5) inhibitors class of medicines. A drug class is a group of pharmaceuticals that all operate in the same way. These medicines are frequently used to treat illnesses that are similar to each other. Sildenafil acts in a variety of ways depending on the problem being treated. 

Sildenafil works to treat erectile dysfunction by boosting blood flow to the penis. This aids in obtaining or maintaining an erection. If you’re sexually stimulated, sildenafil can help with ED.

For PAH: Sildenafil works by relaxing the muscles and opening up the blood vessels in your lungs. The blood pressure in your lungs is reduced as a result of this. Sildenafil helps you feel better by slowing down the progression of your condition. It also improves your ability to workout.

Study and Development

While most studies found that sildenafil had a response rate of around 70%, clinical practice settings have seen a wide variety of response rates, ranging from 86 to 57 percent. 5, 6, 7, 8, 9, 10, 11. This large range implies that the response rate is influenced by a number of factors, including the diversity of research subjects, the length of the treatment period, the number of follow-up visits, the definition of treatment response, and the amount of return rate.

Earlier clinical trials often excluded subjects with cancer, drunkenness, Peyronie’s disease, or penile implants. Because sildenafil is a noninvasive and simple means of therapy, and none of the characteristics can be used to predict total failure,10 sildenafil should be attempted on them first, despite the lower response rate.

The chart review group received the greatest response rate (80.9%), followed by the postal questionnaire (60.2%) and the telephone interview group (60.2%). (54.0 percent ). The disparity appeared to suggest that respondents who gave a poor reaction were less likely to follow up or respond to the questionnaire. To correct this possible bias, the response rate must be adjusted to account for the group of individuals who were lost to follow-up, especially when this proportion of subjects is substantial. 21.4 percent of the patients in our study were lost to follow-up. If the response rate in the research population was as low as that of the telephone interviewed group, the response rate would be reduced from 72.0 percent to 67.9 percent.

Due to the limitations of a retrospective study’s follow-up, treatment efficacy was determined by answering “yes” or “no” to a single simple GEQ, which may be too simplistic to reflect the “wax and wane” nature of individual sexual performance. Our response rate, however, was equivalent to those of other research. In one flexible-dose study, 69 percent of sildenafil recipients had erections sufficient for intercourse on most to all occasions, compared to 23 percent of placebo recipients.12 In a placebo-controlled study conducted in Taiwan, the success rate of sexual intercourse was 62 percent, and the response rate based on their answers to the GEQ, which assessed penile erection improvement, was 88 percent.

It was shown that increasing the dose and having more attempts improved the response rate of sildenafil.2,3 However, our findings in daily practice revealed several flaws: 67 percent of nonresponders did not try the maximum dose of 100 mg, 71.1 percent of nonresponders purchased no more than four tablets, and only 26.5 percent of nonresponders had their prescriptions renewed. They might have benefited from sildenafil medication if they had tried the highest dose, tried again, and received regular follow-ups.

Subjects with psychogenic etiology had the best response rate, followed by those with vasculogenic, and finally those with neurogenic etiology, according to a study. It suggests that sildenafil’s action is more reliant on appropriate nerve input to the corpora than on blood flow. Treatment satisfaction was found to be associated with the severity of the ED in the same study (41 percent in severe ED, 78 percent in moderate, and 100 percent in mild). Despite not being statistically significant in the current study, there is a similar pattern showing that the less the severity of ED, the better the response to sildenafil.

Sildenafil for Men & Women

The oral pill sildenafil is used to treat ED and PAH. For both illnesses, generic oral tablets are available, but brand-name medications only treat one of the problems. Viagra is a medication that is used to treat erectile dysfunction (ED). You can’t get or keep an erection if you have ED. Revatio is a medication that is used to treat PAH. The blood pressure in your lungs is excessively high if you have PAH. Pumping blood into your lungs requires a lot of effort from your heart.

Erectile dysfunction (impotence; inability to get or retain an erection) in men is treated with sildenafil (Viagra). In adults with pulmonary arterial hypertension, sildenafil (Revatio) is used to increase their ability to exercise (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Children should not normally use sildenafil, however, a doctor may decide that sildenafil (Revatio) is the appropriate prescription for a child’s condition in specific situations. Sildenafil belongs to the class of drugs known as phosphodiesterase (PDE) inhibitors. Sildenafil improves blood flow to the penis during sexual stimulation, which helps to treat erectile dysfunction. An erection may result from increased blood flow.

Sildenafil cures PAH by allowing blood to flow freely by relaxing the blood vessels in the lungs. If you’re taking sildenafil to treat erectile dysfunction, keep in mind that it won’t cure it or make you more sexually want. Sildenafil does not protect against pregnancy or sexually transmitted diseases such the human immunodeficiency virus (HIV) (HIV).


Erectile dysfunction progression is slowed.

Using Viagra in a tiny dose every day can help “decrease the intensity of ED progression.” It’s referred to as a “prophylactic.”

Improves urination ability

People’s capacity to urinate increases with the daily use of Viagra. As men age, their prostates grow larger, making it more difficult for them to urinate. The prostate, like the penis, contains a lot of smooth muscle and relaxing it will help the prostate loosen its grip on the urethra. It’s the increased grip that makes it harder to urinate.

​​Enhances the quality of life

Sexual function is substantially tied to male self-esteem, self-confidence, and self-worth. And there have been numerous instances of men using PDE5 inhibitors reporting improved life quality in terms of confidence and satisfaction.

Friendly to the endothelium

PDE5 inhibitors are endothelial-friendly drugs. The endothelium is the blood vessel’s lining. When it is wounded, it develops plaque or atherosclerosis. As a result, taking a PDE5 inhibitor on a daily basis has resulted in “fewer strokes, fewer heart attacks, and stronger erections.

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Side Effects

If the side effects are minor, they may fade gone in a matter of days or weeks. Consult your doctor or pharmacist if they get more severe or don’t go away. Sildenafil oral tablet doesn’t cause drowsiness, but it can induce other side effects, including:

  • nosebleeds
  • headaches
  • upset stomach
  • scrubbing (reddening and warming of the face)
  • problem sleeping
  • fever
  • a longer-lasting erection than usual
  • Infection of the lungs
  • nausea
  • vomiting
  • bronchitis
  • throat irritation
  • a stuffy nose


Erectile dysfunction dosage (ED)

Sildenafil (generic)

Oral tablet form

25 mg, 50 mg, and 100 mg are the strengths available.

Dosage for adults (ages 18–64)

50 mg, given as needed around 1 hour before sexual activity, is a typical dosage. It can be taken anywhere between 30 minutes and 4 hours prior to sexual activity.

100 mg once a day is a maximum dose.

Dosage for children (ages 0–17)

This medicine has not been proven to be safe or effective in children less than 18 years.

Dosage for Seniors (ages 65 years and older)

Older people’s kidneys, livers, and hearts may not function as well as they once did. Your body may process medications more slowly as a result of this. As a result, a greater quantity of medicine remains in your body for a longer period of time. This increases your chances of experiencing negative side effects.

Your doctor may prescribe a lower dose of sildenafil, to begin with. This can help keep the levels of this medicine from rising too high in your system.

Pseudoarterial hypertension (PAH) dosage (PAH)

Sildenafil (generic)

Oral tablet form

20 milligrams of active ingredients

Dosage for adults (ages 18–64)

5 to 20 mg three times a day, around 4 to 6 hours apart, is a typical dosage.

The maximum daily dose is 20 mg, taken three times a day, four to six hours apart.

Dosage for children (ages 0–17)

This medication should not be given to children under the age of 18.

Dosage for Seniors (ages 65 years and older)

Older people’s kidneys, livers, and hearts may not function as well as they once did. Your body may process medications more slowly as a result of this. As a result, a greater quantity of medicine remains in your body for a longer period of time. This increases your chances of experiencing negative side effects.


What is the purpose of sildenafil? 

The drug sildenafil, marketed as Viagra, is used to treat erectile dysfunction by boosting blood flow to the penis during arousal. Sildenafil under the brand name Revatio is often administered to help persons with PAH get more activity by addressing their condition.

What if I forget to bring it with me? 

If you are using Revatio and you forget to take your scheduled dose, take it as soon as possible. However, you should never double your dosage. If you fully miss a dose and it’s time to take the next one, skip it.

Is it appropriate for women to use?

Sildenafil can be used by women to treat pulmonary hypertension. There is no convincing evidence that sildenafil helps women with sexual issues.

Will it have an impact on my fertility?

There is no conclusive evidence that taking sildenafil reduces fertility in men or women. If you’re attempting to get pregnant, talk to a pharmacist or your doctor before taking it.

Will it have an impact on my contraception?

Any method of contraception, including the pill and emergency contraception, is unaffected by sildenafil.


In clinical practice, sildenafil is useful in the treatment of ED with mild AE. There were flaws in everyday practice that were not present in clinical trials or prospective clinical practice-based studies, such as a lack of dose titration, fewer follow-up visits, and insufficient tries before giving up. There were still a few prescriptions for sildenafil written by doctors who didn’t specialize in urology. ED has evolved into a medical condition that is easier to treat after the introduction of sildenafil. Patient and physician education about the ED and the new treatment approach is still a top concern.

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The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.