Tamoxifen all you need to know: Dosage, side effects

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TABLE OF CONTENTS:

  1. What is Tamoxifen?
  2. How Does Tamoxifen Work?
  3. Who Uses Tamoxifen?
  4. Study & Development
  5. Tamoxifen and Bodybuilding
  6. Tamoxifen for Men
  7. Benefits of Tamoxifen
  8. Side Effects of Tamoxifen
  9. Dosage
  10. FAQ (Frequently Asked Questions)
  11. Conclusion

Tamoxifen is a prescription medicine that helps men and women manage and prevent breast cancer. It has been around for more than 30 years. 

Surprisingly, the substance has grown in popularity among bodybuilders. The substance is utilized as an auxiliary drug in anabolic steroid cycles as well as in post-cycle therapy. A substance used to counteract the negative effects of anabolic steroids is known as an ancillary drug.

What is Tamoxifen?

Tamoxifen is a hormone medication that is useful in the treatment of hormone receptor-positive breast cancer. It has the potential to significantly lower the risk of cancer recurrence and invasive malignancy. Tamoxifen is a drug used to reduce the risk of breast cancer in some women. The daily oral medicine inhibits the use of estrogen and progesterone by cancer cells, preventing them from growing and spreading

How Does Tamoxifen Work?

Tamoxifen is a selective estrogen receptor modulator, which is a type of hormonal therapy (SERM). In breast cancer cells, the medication binds to hormone receptors (particular proteins). Once the drug is within the cells, it blocks the cancer from obtaining the hormones they need to multiply and thrive.

Get the full comprehensive take from none other than Dr.Tony Huge on how Tamoxifen proves to be vital specially during a bulking cycle!

Who Uses Tamoxifen?

Tamoxifen is an anti-estrogen drug that can benefit both men and women with hormone receptor-positive breast cancer. The medication can reduce the risk of breast cancer in the following ways:

  • Women who have a strong family history of breast cancer or have mutant (alter) breast cancer (BRCA) genes.
  • Women and men who have already been diagnosed with breast cancer to prevent cancer recurrence, such as:
  • Breast cancer develops in the untreated breast on the other side.
  • Breast cancer recurrence after surgery, chemotherapy, or radiation therapy.
  • If Tamoxifen is right for you, it will be determined by your doctor.
Tony Huge on the long-term use of Tamoxifen

Study and Development

The researchers used smart statistics to show that women over 50 who were administered Tamoxifen had far better results than those who were given chemotherapy. According to their estimations, doctors gave Tamoxifen instead of (or in addition to) chemotherapy to at least 300 of the 16,000 women involved in the trials, saving or prolonging their lives.

Their calculations also revealed that Tamoxifen was just as effective on its own as it was in combination with chemotherapy, saving women months of avoidable side effects. They also suggested that a lengthier treatment period (two years versus one year) would be more helpful. Which is known to be true: new research suggests that women who take Tamoxifen for the full five years instead of only two years have a better probability of surviving breast cancer. Finally, they demonstrated that delivering Tamoxifen at lower doses was just as effective as giving it at greater levels.

This provided definitive evidence that Tamoxifen was an effective treatment for breast cancer in women, as well as a greater understanding of who should receive it, at what dose, and for how long. Back when Tamoxifen was a novel medication, all of this knowledge helped doctors make the best decisions possible when prescribing it.

Breast cancer has been progressively increasing in the number of women (and, in a rare occasion, men) diagnosed throughout the years. Breast cancer has become the most frequent type of cancer in the United Kingdom since 1997. ER positive breast cancer affects eight out of every ten of the 48,000 women diagnosed with breast cancer in the UK each year — nearly the same number of women as 500 double-decker buses.

The work in establishing Tamoxifen’s potency ensured that it became a standard treatment for people with this kind of breast cancer. Today, about two-thirds of women diagnosed with breast cancer this decade are expected to live for 20 years or more, thanks in part to this.

Tamoxifen and Bodybuilding

Tamoxifen is commonly used to prevent gynecomastia by suppressing estrogenic action in breast tissue, which it may do quite successfully during the cycle. It won’t completely eliminate the risk of gyno, especially with progesterogenic steroids, for which a prolactin-lowering vitamin like Vitex will be required. Assuming, of course, that your cycle went well, that you followed up with a PCT, and that you overcame the Tamoxifen-induced suppression of sex drive, low IGF-1 levels, and low free testosterone levels.

What happens if you stop taking Tamoxifen? Multiple studies demonstrate a significant increase in estrogen levels in the body with Tamoxifen use, its removal will result in high estrogen levels in the body with nothing to prevent this estrogen from developing gyno in male bodybuilders. This sets the stage for the type of rebound gyno that you typically hear about on bodybuilding message boards. To add insult to injury, elevated estrogen levels are restrictive in and of themselves, resulting in slowed gym development on going off Tamoxifen.

Tamoxifen for Men

Tamoxifen, a hormone medication, is frequently used to treat males who have been diagnosed with breast cancer. Many men experience troubles when taking Tamoxifen. According to a study, about 20% of them discontinue taking it, on their own or as recommended by their doctors, due to intolerable side effects. Breast cancer in men is a rare occurrence since in 2011, approximately 2,100 new cases of invasive breast cancer in men were accurately diagnosed. Breast cancer is around 1 in 1,000 times more likely in men than in women.

​​Male breast cancer, like female breast cancer, is mostly hormone-receptor positive. Estrogen and progesterone are hormones that may help hormone-receptor-positive breast tumors grow and spread. As a result, hormonal therapy that blocks the effects of these hormones, such as Tamoxifen, can be an effective treatment option for both men and women with hormone-receptor-positive breast cancer. Researchers examined the treatment records of 126 males diagnosed with breast cancer between 1999 and 2009 in another study. The majority of the men had early-stage breast cancer, although several had advanced-stage cancer as well. Tamoxifen was given to around 64 men or around half of the patients.

If you’ve been diagnosed with breast cancer as a man, you may be prescribed Tamoxifen or similar hormonal therapy. If you are experiencing side effects that you feel are due to your therapy, talk to your doctor about them and how you might reduce them. You might also wish to inquire about alternative treatments that might be appropriate for your case. It’s best to see your doctor before discontinuing treatment on your own.

Benefits of Tamoxifen

Tamoxifen is a trustworthy form of medication since it has been used to treat millions of women and men diagnosed with hormone-receptor-positive breast cancer since its approval in 1998. Tamoxifen can provide people with the following:

  • Strengthen and bulk up your muscles
  • Encourage a leaner and tougher physique.
  • Boost your athletic abilities
  • Reduces chances of breast cancer by 30% to 50% in women
  • Lessens the chance of new cancer in breast by roughly 50%
  • Minimizes big, hormone-receptor-positive breast tumors
  • Delays or stops the progression of breast cancer hormones
  • Reduces breast cancer risk in susceptable women 
  • Assists in preventing bone loss after menopause
  • Diminished cholesterol levels

Tamoxifen has health benefits that aren’t tied to cancer treatment such as for bodybuilding. Because it’s a SERM, it selectively either blocks or enhances estrogen’s activity on specific cells.

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Side Effects of Tamoxifen

Blood clots, stroke, and endometrial cancer are among major side effects of Tamoxifen’s specific estrogen activation actions. Tell your doctor if you smoke or have a history of blood clots or heart attacks if you and your doctor are contemplating Tamoxifen as part of your treatment plan. If you’re taking Tamoxifen, contact your doctor right away if you experience any of the following symptoms:

  • Vaginal Bleeding Or Discharge That Is Unusual
  • In The Pelvis, There Is Pain Or Pressure.
  • Tenderness Or Swelling In The Legs
  • Chest Discomfort
  • Breathing Problems
  • Face, Arm, Or Leg Weakness, Tingling, Or Numbness
  • Difficulty In Communicating Or Comprehending
  • Issues With Vision
  • Dizziness
  • Severe Headaches All Of A Sudden
  • Increased Tumor Or Bone Pain
  • Hot Flashes
  • Nausea
  • Fatigue
  • Mood Swings
  • Depression
  • Headache
  • Hair Thinning
  • Constipation
  • Dry Skin
  • Loss Of Libido

Dosage

This medicine’s dosage will vary depending on the patient. Follow your doctor’s orders or the label’s instructions. Only the typical doses of this drug are included in the following information. If your dose differs, do not alter it unless your doctor instructs you to.

The amount of medicine you take is determined by the medicine’s strength. In addition, the number of dosages you take each day, the duration between doses, and the length of time you take the medicine are all determined by the medical problem for which the medicine is being used.

For oral administration (solutions and tablets):

  • For breast cancer, take the following steps:
    • Adults should take between 20 and 40 milligrams (mg) each day. Doses larger than 20 mg are divided into two daily doses (morning and evening).
    • Your doctor will determine the appropriate use and dosage for your child.
  • Additional treatment for breast cancer:
    • Adults should take 20 mg each day for 5 to 10 years.
    • Your doctor will determine the appropriate use and dosage for your child.
  • In order to reduce the risk of breast cancer in high-risk women, the following steps should be taken:
    • Adults should take 20 milligrams (mg) every day for the next five years.
    • Your doctor will determine the appropriate use and dosage for your child.
  • In order to reduce the risk of invasive breast cancer in women with ductal carcinoma in situ, the following treatments should be used:
    • Adults should take 20 milligrams (mg) every day for the next five years.
    • Children—Usage and dosage must be determined by a doctor.

FAQs

When should I consult a physician?

If you’re taking Tamoxifen and you’re having any of the following symptoms, you should contact your doctor.

  • Shortness of breath or chest pain.
  • Fever.
  • Slurred speech, blurred vision, or abrupt numbness in the legs, arms, or face are all signs of a stroke.
  • Legs, ankles, and feet swelling.
  • Vomiting that is out of control

Is Tamoxifen safe to take during pregnancy?

Tamoxifen has been linked to birth abnormalities. If you’re pregnant or planning to get pregnant, you shouldn’t take the drug. Consult your healthcare practitioner about nonhormonal birth control choices to avoid pregnancy. (Hormonal contraceptives have been shown to hasten the progression of hormone-positive breast cancer.) While using Tamoxifen and for two months after stopping it, you should utilize contraception.

What are the dangers of Tamoxifen use?

Tamoxifen can produce serious side effects in certain people, including:

  • Strokes, blood clots, and deep vein thrombosis (DVT).
  • Cataracts or other vision issues.
  • Endometrial (uterine) cancer is a type of cancer that affects the endometrium.

When it comes to Tamoxifen, how long should you take it?

The majority of women take Tamoxifen or other hormone therapy for at least five years, and in rare cases up to ten. The length of your treatment is determined by the characteristics of your cancer diagnosis. Your doctor may advise you to take Tamoxifen for five years before switching to another hormone therapy for several years.

What is the efficacy of Tamoxifen?

Tamoxifen has been used to prevent or treat breast cancer by millions of people. The medication may reduce your chances of:

  • By 50%, breast cancer in the opposite breast is reduced.
  • Breast cancer recurrence is 30% to 50% higher in premenopausal women.
  • Breast cancer recurrence is estimated to be 40% to 50% higher in postmenopausal women.
  • Up to 40% of breast cancer diagnoses are missed.
  • By up to 50% following a diagnosis of early-stage, noninvasive breast cancer (ductal carcinoma in situ or DCIS), invasive breast cancer develops.

Conclusion

The importance of training and diet during the cycle cannot be overstated. Taking the drug without engaging in adequate exercise and following a well-planned diet will only lead to disappointment. To gain muscle, you must exercise and consume a well-balanced diet. Muscle-building activities and strength-training exercises must be combined in your training; ask your gym teacher for more information on the two. Meat, eggs, cheese, milk, and yogurt are all good bodybuilding foods to include in your diet. 

To prevent fat deposits in your blood vessels, limit your intake of cholesterol-rich foods. To help digestion, eat fiber-rich fruits and vegetables. Foods high in potassium should not be avoided if you are taking steroids with Tamoxifen (steroids deplete potassium levels). You should consult a nutritionist for advice on the optimal diet for bodybuilding. Enough said; if you’re thinking about starting a steroid cycle and want to avoid gyno and fluid retention, this is an anti-estrogen you can trust, and you’ll be the one to tell others about its benefits.

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DISCLAIMER:

The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.