The Side Effects of Tesofensine No One Talks About

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Table of Contents
  1. What is Tesofensine?
  2. Common Side Effects
  3. Conclusion

What is Tesofensine?

Tesofensine is a medication that is currently being studied as a treatment for obesity and type 2 diabetes.  Tesofensine works by increasing levels of serotonin, noradrenaline, and dopamine by inhibiting their reuptake of them.   Originally the drug was designed for people with mental health issues as an antidepressant, but during the clinical trials, an unexpected effect of it was that it caused rapid weight loss in the populations using it.  The drug has recently caught fire in biohacking communities as it is a great combination of a nootropic and a powerful weight loss agent.  While the drug has shown promising results in clinical trials, it also has a number of side effects that patients should be aware of.


Common Side Effects

The most common side effects of tesofensine include nausea, diarrhea, constipation, and headache. These side effects are usually mild and can be managed with over-the-counter medications. However, some patients may experience more severe symptoms such as abdominal pain, vomiting, and weight loss.  These are going to be the mildest and most common side effects, but still can be present.  It is always important to be aware that these side effects are possible so that you can appropriately adjust your supplement protocol.

Increase in Blood Pressure

Another side effect of tesofensine is an increase in heart rate and blood pressure. This can be a concern for patients with pre-existing heart conditions or hypertension. It is recommended that patients taking tesofensine should have their heart rate and blood pressure monitored regularly to ensure that they are not experiencing any negative changes.  This is especially important in the bodybuilding world as a lot of bodybuilders already tend to struggle a lot with blood pressure issues.  High blood pressure can be catastrophic for your heart, kidneys, and brain, and should be addressed immediately.

Changes in Mood and Sleep

Tesofensine can also cause changes in mood and sleep patterns.  Some users taking tesofensine may notice that their sleep is negatively impacted by using this drug.  This is likely due in part to its ultra-long half-life and its increasing neurotransmitters like noradrenaline.  By taking the drug upon waking and moving to dosing EOD you can alleviate some of the side effects that are related to sleep.  By also establishing a good sleep supplement stack and sleep hygiene you can do an amazing job at helping to fix certain sleep issues.

Tesofensine can also alter a person’s mood pretty greatly. Of course, this makes sense as it was originally designed as an antidepressant.  There is a lot of variety when it comes to antidepressants.  Every single individual’s brain chemistry is different and so while Tesofensine works very well for some people other people notice that it negatively impacts their mood and makes them tired or lethargic.  Tesofensine also carries a risk of addiction and withdrawal symptoms. Patients should be monitored for signs of addiction and should not stop taking the medication suddenly.


Overall, tesofensine is a promising medication for the treatment of obesity and type 2 diabetes. However, it does have a number of side effects that patients should be aware of. Patients taking tesofensine should be closely monitored by their healthcare provider to ensure that they are not experiencing any dangerous side effects.  It’s worth noting that Tesofensine is still in clinical trials and not yet approved for use by any regulatory body, therefore more studies are needed to determine the long-term safety and efficacy of this drug.


The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability

  • Axel AM, Mikkelsen JD, Hansen HH. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology. 2010 Jun;35(7):1464-76. doi: 10.1038/npp.2010.16. Epub 2010 Mar 3. PMID: 20200509; PMCID: PMC3055463.
  • Bentzen BH, Grunnet M, Hyveled-Nielsen L, Sundgreen C, Lassen JB, Hansen HH. Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats. Obesity (Silver Spring). 2013 May;21(5):985-92. doi: 10.1002/oby.20122. PMID: 23784901.
  • Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial. Lancet. 2008 Nov 29;372(9653):1906-1913. doi: 10.1016/S0140-6736(08)61525-1. Epub 2008 Oct 22. PMID: 18950853.