TUDCA+ (Tauroursodeoxycholic Acid) Ultimate Guide: Dosage, Side Effects, Benefits

 »  »  TUDCA+ (Tauroursodeoxycholic Acid) Ultimate Guide: Dosage, Side Effects, Benefits
0 Comments

TABLE OF CONTENTS:

  1. What is TUDCA?
  2. How Does TUDCA Work?
  3. TUDCA and Bodybuilding
  4. Study and Development
  5. Benefits
  6. Side Effects
  7. Dosage
  8. FAQ (Frequently Asked Questions)
  9. Conclusion

There’s a new type of functional medicine out there! We’ll go over the benefits of TUDCA as well as the overall effects it can have in this review.

More importantly, we’ll look at the science underlying TUDCA’s use in humans, including where it originates from, the proper TUDCA dose range, and the specific results you can expect.

TUDCA has been related to a drastic reduction in body weight. So, how much weight can you lose and how soon can you lose it? Continue reading to find out.

What is TUDCA?

TUDCA stands for Tauroursodeoxycholic acid, which is a bile acid that is found in trace amounts in the human body. Bile acids are substances produced by the gallbladder that aid in the digestion of lipids. TUDCA, unlike UDCA, is not an FDA-approved medicine in the United States. URSO, or ursodiol, is another name for UDCA. UDCA has been approved to treat individuals with primary biliary cirrhosis, an autoimmune liver disease.

TUDCA and ursodeoxycholic acid are nearly identical molecules (UDCA). TUDCA is UDCA with the addition of (conjugated) taurine. Both bile acids and bile acids function on the same biological pathways. In the body, their solubility and bioavailability differ just little. There is some evidence that TUDCA can be used for disorders other than liver disease, but additional research is needed.

TUDCA is marketed as a dietary supplement. TUDCA supplements, on the other hand, have not been approved by the FDA for medical use. In general, there isn’t a lot of clinical study on supplements. Regulations establish manufacturing standards, but they do not ensure their safety or effectiveness. Before taking any supplements, consult your doctor.

TUDCA bulk items from China are being used for research reasons, according to the FDA. These products may be tainted and are making their way into the United States without being checked.

How Does It Work?

Both UDCA and TUDCA are effective apoptosis inhibitors, in part by interfering with the upstream mitochondrial mechanism of cell death, suppressing oxygen radical formation, lowering ER stress, and stabilizing the unfolded protein response (UPR). TUDCA acts as an anti-apoptotic agent in a range of neurodegenerative illnesses, including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, according to several studies. TUDCA also plays a crucial role in the prevention of cell death in certain retinal diseases, such as retinitis pigmentosa.

Twenty obese men and women with insulin resistance participated in a randomized controlled experiment.TUDCA medication (1750 mg/day) resulted in a 30% increase in insulin sensitivity in the liver and muscle after 4 weeks. Despite the fact that TUDCA is said to reduce ER stress, markers of ER stress were not changed in these subjects (from adipose tissue biopsy). As a result, the precise molecular pathways causing the improved insulin sensitivity remain unknown. TUDCA’s preventive effects in healthy persons without insulin resistance are still unknown.

By suppressing caspase activation, up-regulating the UPR, and inhibiting reactive oxygen species, it has been found to alleviate ER stress associated with high glucose levels in diabetes. T/UDCA could be used to treat obesity, stroke, acute myocardial infarction, spinal cord injury, and a slew of other acute and chronic non-liver disorders linked to apoptosis. A growing number of pre-clinical and clinical research show that this basic, naturally occurring bile acid, which has been utilized in Chinese medicine for over 3000 years, may have health benefits.

TUDCA and Bodybuilding

TUDCA should be used in every steroid cycle regimen to help protect your body from negative side effects. Someone who uses a moderate dose of oral steroids over time can put their liver under a lot of stress. Steroids induce cell damage as they move through the liver and are metabolized. Steroids can cause jaundice and significant liver disease by damaging liver cells. Furthermore, steroids can cause cholestasis, which is a condition in which the liver’s generation and flow of bile is directly inhibited. TUDCA has been utilized to aid bile flow (relieve cholestasis) and liver cleansing.

TUDCA isn’t simply for steroid cycles anymore. It should be utilized in post-cycle therapy as well (PCT). When you’re on a steroid cycle, your heart and liver are going to be put under a lot of stress. Continuing to cleanse your body after you’ve stopped taking steroids will assist you discharge the toxins you’ve accumulated. This should help you feel better and get you back to where you were before the cycle began. Those who blast and cruise (BnC) can also benefit from TUDCA, as it effectively cleanses the liver even during BnC runs. It just implies that there will be more blasting and less cruising.

TUDCA therapy inhibited the NFkB pathway, which lowered the synthesis of nitrites by microglial cells and astrocytes in a mouse model of neuroinflammation (LPS injection). Reduced glial cell activation, reduced microglial cell migratory capacity, and 3) reduced expression of chemoattractants (e.g., MCP1) and vascular adhesion proteins (e.g., VCAM1), which are required for microglial migration and blood monocyte invasion to the brain inflammation site, were found to have a triple anti-inflammatory effect on glial cells.

Study and Development

The most persuasive study for neuroprotection is one conducted in an Alzheimer’s mice model (APP/PS1) in which treatment was initiated after pathology had developed (7 months old). TUDCA therapy (500 mg/kg, i.p., every 3 days) reduced A deposition (A40 and A42) in the frontal cortex and hippocampus after 3 months. TUDCA inhibits the amyloidogenic processing of amyloid precursor protein, indicating that it interferes with A formation. TUDCA significantly reduced glial activation and the generation of proinflammatory cytokine RNA (TNF), while partially restoring synaptic function. loss.

TUDCA was able to reduce A generation and deposition, tau pathology, glial activation, and synaptic function loss even when started after the onset of the disease. The stimulation of the Akt/GSK3 signaling pathway is thought to be responsible for the majority of these effects. There is only a tendency toward better spatial memory. TUDCA-treated APP/PS1 mice were found to have substantial cognitive deficits, which was likely due to the fact that these mice already had extensive cognitive abnormalities. 

TUDCA diet (0.4 percent mixed in food) was started at 2 months of age (before considerable amyloid deposition) and continued for 6 months in the same mouse model, according to several studies.It is possible to avoid spatial, recognition, and contextual memory deficits. Modulation of the activity of the -secretase played a role in these actions. The same treatment paradigm also prevented a decrease in PSD95 expression, implying a synaptic neuroprotective role for TUDCA.

There have been reports of other putative neuroprotection pathways. TUDCA has been proven in an in vitro research to directly reduce A-induced alteration of mitochondrial membrane structure, which is linked to mitochondrial health. TUDCA decreases p53-induced apoptosis and alters expression of the anti-apoptotic Bcl2 family of proteins, according to a study from a cell culture model of Alzheimer’s disease. TUDCA also inhibits connective tissue growth factor (CTGF), a protein found in the vicinity of A plaques and neurofibrillary tangles that modulates -secretase activity.

TUDCA was also found to be neuroprotective in mouse models of Huntington’s disease. In the mouse striatum, TUDCA boosted neuronal survival, maintained mitochondria, and reduced huntingtin inclusions while improving cognitive and sensorimotor impairments. “TUDCA can be administered orally or intravenously, is accessible to the brain and other organs, and exhibits basically little toxicity,” the authors wrote.

TUDCA treatment has been demonstrated to improve outcomes in randomized controlled trials.

hepatic function in individuals with cirrhosis, HCV-related chronic hepatitis, and cholestasis (a disease in which bile does not move from the liver to the intestines). duodenum. TUDCA significantly reduces serum liver enzymes, which are markers of liver inflammation, according to these studies (ALT, AST, and ALP). TUDCA has a strong effect on cholestasis and is utilized as a reference medication for these effects.

Benefits

Mitochondria and cellular support don’t sound all that amazing until we explain what they mean. Mitochondria can be found in every cell of the body, and they create over 90% of the body’s energy at the cellular level. TUDCA can increase the health and stability of this by producing more antioxidants, reducing free radicals, cellular mutations, and regulating apoptosis (programmed cell death).

TUDCA may aid in the maintenance of insulin sensitivity. When taken as directed, this supplement has been shown to lower blood glucose levels significantly. Blood sugar levels were reduced by up to 43% in animal trials, which could have a significant influence on diabetes. TUDCA supplementation has been shown to result in a significant increase in biliary flow. That implies improved digestion, more complete absorption of essential nutrients, and a faster and more complete exit from the body for harmful substances like cholesterol and other toxins.

TUDCA has been the subject of various investigations on neuroprotective chemical characteristics due to its ease of penetrating the blood-brain barrier. It’s also been demonstrated to be a “chemical chaperone,” which can help move proteins to their proper destination in the brain, where inadequate processing could cause them to build up and cause cognitive loss. When used as a dietary supplement, however, TUDCA’s benefits rise to include:

  • Support for digestion (increased fat digestion)
  • Possibility of weight loss
  • Improving insulin sensitivity at the start
  • Improved eye health
  • Detoxification of the body
  • Properties that protect the brain
  • Mitochondria and cellular assistance
  • Improved liver function
  • Absorption of nutrients is improved.
  • Gut health has improved.
  • Protection for the kidneys

ULTIMATE Body Protectant STARTS TODAY!

CODE “MATRIX10” – 10% discount

Side Effects

The use of UDCA, which is identical to TUDCA, has been linked to the following side effects:

  • Pre-existing psoriasis gets worse
  • Other skin problems (rash, urticaria, dry skin)
  • Sweating
  • Thinned hair
  • Cholecystitis and biliary discomfort
  • Digestive issues (constipation, stomatitis, flatulence)
  • Headache
  • Fatigue
  • Distressed mental health (anxiety, depression, sleep disorder)
  • Back discomfort, arthralgia, and myalgia
  • Cough and rhinitis are two common symptoms of rhinitis.

Dosage

Over the course of six months, a dose-response trial of TUDCA evaluated doses of 500 mg, 1000 mg, and 1500 mg per day, finding little variation in liver markers between the doses. The most effective dose for reducing enzyme levels was 1500 mg, while the most cost-effective dose was 500 mg.

According to one study, a tolerable and administrable dose for humans is 60 mg/kg/day. TUDCA, when taken at a dose of 10–13 mg per day for three months, can lower liver enzyme levels. TUDCA was utilized at a dose of 15–20 mg/kg body weight to improve bile salt composition.

Doses of 1,750 mg daily have been tolerated for up to four weeks in otherwise healthy obese people. TUDCA 500 mg daily for a year was found to have no negative side effects in liver transplant patients.

TUDCA (750 mg daily for two months) was well tolerated in patients with PBC. Another trial indicated that 1500 mg of TUDCA daily for six months was well tolerated in patients with PBC.

FAQ

Why is bile important?

Water, acids, electrolytes, and other organic compounds make up bile, which is a complicated fluid. The most functional component of bile, bile acids, aid in the digestion and absorption of fat-soluble vitamins A, D, E, and K. Bile also aids in the digestion of nutrients, cholesterol, and the destruction of dangerous germs.

How Do UDCA and TUDCA Bile Salts Differ?

The liver produces primary bile acids with cholesterol as a starting material. UDCA returns to the liver and is conjugated with taurine to generate TUDCA as bile acids flow (through enterohepatic circulation). This procedure avoids cell death while also reducing endoplasmic reticulum (ER) stress (aka apoptosis).

What is the origin of TUDCA?

TUDCA has been used for generations in Chinese traditional medicine to treat a variety of diseases. It was initially derived from the bile of bears in Chinese medicine. TUDCA accounts for more than half of the TUDCA in bear bile. This, according to some scientists, is what allows bears to hibernate for long periods of time.

Is TUDCA licensed?

TUDCA has been licensed for the treatment of liver problems in Italy. Furthermore, the European Medicines Agency has given it the status of ‘orphan designation’ (EMA). Orphan status is awarded to medications that meet three criteria: they are used to treat a highly serious ailment, there are no other medicines to treat the disease/condition, and the condition is rare, or the manufacturer of the medicine will see a low return on investment.

Conclusion

TUDCA appears to be a very low-risk technique of improving various good benefits in the body while also assisting in the reduction of some longer-term issues that can be rather problematic.

The key advantage is that it has a link to enhanced brain health in the long run, as well as greater mitochondrial activity. Aside from that, you get the short-term benefits of improved digestion, absorption, and waste disposal from the body (especially cholesterol).

TUDCA supplements are commonly available. Buying them from a specialized online store with a track record of batch testing through independent third-party labs, on the other hand, ensures that what you’re getting is pure and effective.

Swiss Chems TUDCA Sodium 10 grams
CODE “MATRIX10” – 10% discount

DISCLAIMER:

The information provided above is not intended to substitute professional medical advice, diagnosis, or treatment. Always seek your physician’s advice or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read. We bear no responsibility or liability for your use of any compound.